Predicting Dietary Selenium Needs to Achieve Target Blood Selenium Levels
18 Years
N/A
Both
Nutritional Requirements
Trial Information
Predicting Dietary Selenium Needs to Achieve Target Blood Selenium Levels
Results of studies with animal tumor models and human clinical trials suggest that the
essential nutrient selenium can be anti-tumorigenic if consumed at levels greater than
nutritional requirements. If it is possible to increase plasma selenium concentrations
above 120 nanograms per milliliter with less than 200 micrograms of selenium daily, then it
is possible that supplementation can be accomplished through the use of selenium-containing
foods.
Inclusion Criteria:
- able to swallow capsules
- body mass index less than 40
Exclusion Criteria:
- Pregnancy
- Chronic liver or kidney disease
- taking medication that might affect liver and/or kidney
- blood pressure 140/90 or higher
- already taking more than 50 micrograms of selenium
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
Outcome Measure:
Evaluation of effectiveness of consuming oral doses of L-selenomethionine in raising plasma selenium concentrations
Outcome Time Frame:
Baseline, and after 3, 6, 9, and 12 months of supplementation
Safety Issue:
No
Principal Investigator
Gerald F Combs, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
USDA Grand Forks Human Nutrition Research Center
Authority:
United States: Federal Government
Study ID:
GFHNRC009
NCT ID:
NCT00803699
Start Date:
November 2005
Completion Date:
September 2007
Related Keywords:
- Nutritional Requirements
- selenium
Name | Location |
|---|---|
| USDA Grand Forks Human Nutrition Research Center | Grand Forks, North Dakota 58202 |
