Pilot Study on Transient Bacteremia and Blood Stream Infections After Invasive Dental Procedures in Cancer Patients With Central Venous Catheters

Inclusion Criteria

Inclusion criteria

- Patients willing and able to provide written informed consent for the study.

- Patients diagnosed with cancer and being treated at the University of Connecticut
Health Center.

- Patients scheduled to receive or who have received a central venous catheter

- Patients who have at least one tooth.

Exclusion criteria

- Patients under the age of 18

- Patients who have received any antibacterial in the time period starting 48 hours
before the dental cleaning. This includes systemic antibacterials and topical
antibacterials in the oral cavity or at/through the CVC site. (Topical antibacterials
at other sites are allowed; antifungal and antiviral agents in any form are allowed).

- Patients who plan to use antibacterials within the 24 hours after the procedure
(until the final blood sample is obtained).

- Patients with a documented blood stream infection within 1 month prior to proposed
dental cleaning.

- Patients with a clinically significant coagulation disorder or patients on warfarin.

- Patients who require antibiotic prophylaxis as per ACC/AHA 2007 guidelines, namely;

- patients who have had a cardiac transplantation,

- incomplete cardiac valve repair,

- complete cardiac valve repair in last 6 months,

- prior history of infective endocarditis ,

- patients with a prosthetic cardiac valve.

- Patients with any other condition which might preclude participation in the opinion
of the patient's physician(s) or the study PI's.