Inclusion Criteria:

- Metastatic colorectal cancer, histologically or cytologically confirmed

- Age 18 or greater

- Adequate hematologic function (ANC > 1500, hemoglobin > 10 g/dl, platelet count >
100,000)

- Adequate hepatic parameters (bilirubin < 2.0, Alk. Phos < 5 times normal, ALT < 5
times normal)

- Adequate renal function (creatinine < 2.0)

- Performance status ECOG 0-2

- 0-2 prior lines of chemotherapy for metastatic colorectal cancer are allowed. Prior
5-FU/LV or capecitabine allowed either in the adjuvant setting, or in the metastatic
setting or both.

- Absence of other serious concurrent medical illnesses

- Evaluable or measurable disease for phase I; measurable disease only for phase II

Exclusion Criteria:

- Histologies other than adenocarcinoma

- Previous grade 4 toxicity to 5-FU +/- LV or capecitabine

- Uncontrolled brain metastases

- Chronic diarrhea (greater than five bowel movements per day)

- Previous chemotherapy or radiation therapy less than 4 weeks prior to study day 1
(less than 6 weeks for chemotherapy with Mitomycin or nitrosoureas)

- Major surgery within 2 weeks before study entry

- Known allergic sensitivity to leucovorin

- Prior exposure to IFN-γ

- Previous hematopoietic growth factor (e.g. epoetin alfa or darbepoietin less than 2
weeks prior to study day 1)

- Pregnancy or breast feeding. Women of child-bearing potential must have a negative
pregnancy test before the first dose.

- Other co-existing malignancies or malignancies diagnosed within the last 5 years,
with the exception of basal cell carcinoma or cervical cancer in situ

- Inability to provide written and informed consent

- Uncontrolled hypertension

- History of deep venous thrombosis or CVA

- Prior exposure to bevacizumab

- Proteinuria > 500 mg/24 hr