Inclusion Criteria:

Each patient must meet all of the following inclusion criteria to be enrolled in the
study:

1. Age 18 to 80

2 Diagnosis of moderately to severely active ulcerative colitis

3. Demonstrated, over the previous 5 year period, an inadequate response to, loss of
response to, or intolerance of at least one conventional therapy as defined by the
protocol

4. May be receiving a therapeutic dose of conventional therapies for IBD as defined by the
protocol

Exclusion Criteria:

1. Evidence of abdominal abscess at the initial screening visit

2. Extensive colonic resection, subtotal or total colectomy

3. Ileostomy, colostomy, or known fixed symptomatic stenosis of the intestine

4. Have received non permitted IBD therapies within either 30 or 60 days, depending on
the medication, as stated in the protocol

5. Chronic hepatitis B or C infection

6. Active or latent tuberculosis