Neuropsychological, Social, Emotional, and Behavioral Outcomes in Children With Cancer
N/A
1 Month
21 Years
1 Month
21 Years
Open (Enrolling)
Both
Chemotherapeutic Agent Toxicity, Cognitive/Functional Effects, Neurotoxicity, Psychosocial Effects of Cancer and Its Treatment, Radiation Toxicity, Unspecified Childhood Solid Tumor, Protocol Specific
Both
Chemotherapeutic Agent Toxicity, Cognitive/Functional Effects, Neurotoxicity, Psychosocial Effects of Cancer and Its Treatment, Radiation Toxicity, Unspecified Childhood Solid Tumor, Protocol Specific
Trial Information
Neuropsychological, Social, Emotional, and Behavioral Outcomes in Children With Cancer
OBJECTIVES:
I. To utilize a standardized battery of age-appropriate neuropsychological and behavioral
tests in conjunction with Children's Oncology Group (COG) Phase III clinical trials to
evaluate cognitive, social, emotional, and behavioral functioning over time.
II. To institute procedures to ensure a consistent, streamlined, and efficient
administration of the neuropsychological/behavioral tests in a cooperative group setting in
order to maximize compliance with a standardized assessment battery conducted at 3
standardized timepoints.
OUTLINE:
Parent and child participants complete the COG Standard Neuropsychological and Behavioral
Battery testing at 9, 30, and 60 months post-diagnosis in a 1-hour session conducted by a
neuropsychologist or psychologist. The Battery consists of tests of intelligence, processing
speed/attention, memory, language preference, general developmental progress, attention and
behavior/social/emotional function, executive function, adoptive function, and quality of
life. Additionally, parents complete a parent-report questionnaire to gather information
about patient's function in terms of attention, memory, executive abilities, and behavioral,
social, and emotional adaption.
Inclusion Criteria:
- Diagnosis of cancer
- Must be currently enrolled on a COG therapeutic study that aims to examine
neuropsychological, social, emotional, and/or behavioral functioning
- Must have receptive and expressive English language skills
- Patients with a history of severe or profound mental retardation (i.e. intelligence
quotient [IQ] =< 50) are not eligible for enrollment
- Children with a prior history of attention deficit hyperactivity disorder (ADHD)
or a specific learning disability (e.g. dyslexia) are eligible for this study
- All patients and/or their parents or legal guardians must sign a written informed
consent
Type of Study:
Observational
Study Design:
Time Perspective: Prospective
Outcome Measure:
Consistent, streamlined, and efficient administration of neuropsychological and behavioral tests
Outcome Time Frame:
Not Provided
Safety Issue:
No
Principal Investigator
Leanne Embry
Investigator Role:
Principal Investigator
Investigator Affiliation:
Children's Oncology Group
Authority:
United States: Institutional Review Board
Study ID:
ALTE07C1
NCT ID:
NCT00772200
Start Date:
September 2008
Completion Date:
Related Keywords:
- Chemotherapeutic Agent Toxicity
- Cognitive/Functional Effects
- Neurotoxicity
- Psychosocial Effects of Cancer and Its Treatment
- Radiation Toxicity
- Unspecified Childhood Solid Tumor, Protocol Specific
- Neurotoxicity Syndromes
- Radiation Injuries
Name | Location |
|---|---|
| Baylor College of Medicine | Houston, Texas 77030 |
| Johns Hopkins University | Baltimore, Maryland 21205 |
| Memorial Sloan Kettering Cancer Center | New York, New York 10021 |
| Cleveland Clinic Foundation | Cleveland, Ohio 44195 |
| Roswell Park Cancer Institute | Buffalo, New York 14263 |
| Mayo Clinic | Rochester, Minnesota 55905 |
| Children's Hospital of Philadelphia | Philadelphia, Pennsylvania 19104 |
| University of Iowa Hospitals and Clinics | Iowa City, Iowa 52242 |
| University of Mississippi Medical Center | Jackson, Mississippi 39216-4505 |
| Washington University School of Medicine | Saint Louis, Missouri 63110 |
| University of Texas Health Science Center at San Antonio | San Antonio, Texas 78284-7811 |
| Midwest Children's Cancer Center | Milwaukee, Wisconsin 53226 |
| Bronson Methodist Hospital | Kalamazoo, Michigan 49007 |
| Vanderbilt-Ingram Cancer Center | Nashville, Tennessee 37232-6838 |
| Loyola University Medical Center | Maywood, Illinois 60153 |
| Morristown Memorial Hospital | Morristown, New Jersey 07962-1956 |
| Marshfield Clinic | Marshfield, Wisconsin 54449 |
| Newark Beth Israel Medical Center | Newark, New Jersey 07112 |
| New York Medical College | Valhalla, New York 10595 |
| Dana-Farber Cancer Institute | Boston, Massachusetts 02115 |
| Cedars-Sinai Medical Center | Los Angeles, California 90048 |
| University of Nebraska Medical Center | Omaha, Nebraska 68198-3330 |
| Hackensack University Medical Center | Hackensack, New Jersey 07601 |
| Children's Hospital Los Angeles | Los Angeles, California 90027-0700 |
| Children's National Medical Center | Washington, District of Columbia 20010-2970 |
| All Children's Hospital | St. Petersburg, Florida 33701 |
| Advocate Hope Children's Hospital | Oak Lawn, Illinois 60453 |
| Saint Jude Midwest Affiliate | Peoria, Illinois 61637 |
| Carolinas Medical Center | Charlotte, North Carolina 28232-2861 |
| University of Oklahoma Health Sciences Center | Oklahoma City, Oklahoma 73104 |
| St. Jude Children's Research Hospital | Memphis, Tennessee 38105-2794 |
| Driscoll Children's Hospital | Corpus Christi, Texas 78466 |
| Southern California Permanente Medical Group | Downey, California 90242 |
| Children's Hospital Central California | Madera, California 93638-8762 |
| Kosair Children's Hospital | Louisville, Kentucky 40202-3830 |
| Overlook Hospital | Summit, New Jersey 07902-0220 |
| Cincinnati Children's Hospital Medical Center | Cincinnati, Ohio 45229-3039 |
| Methodist Children's Hospital of South Texas | San Antonio, Texas 78229-3993 |
| Primary Children's Medical Center | Salt Lake City, Utah 84113-1100 |
| Montefiore Medical Center | Bronx, New York 10467-2490 |
| Rady Children's Hospital - San Diego | San Diego, California 92123-4282 |
| Children's Hospitals and Clinics of Minnesota - Minneapolis | Minneapolis, Minnesota 55404 |
| University of New Mexico Cancer Center | Albuquerque, New Mexico 87131-5636 |
| Nationwide Children's Hospital | Columbus, Ohio 43205-2696 |
| Children's Hospital of Pittsburgh of UPMC | Pittsburgh, Pennsylvania 15213 |
| Dell Children's Medical Center of Central Texas | Austin, Texas 78723 |
| Children's Hospital and Research Center at Oakland | Oakland, California 94609-1809 |
| Presbyterian Hospital | Charlotte, North Carolina 28233-3549 |
| Lee Memorial Health System | Fort Myers, Florida 33902 |
| University of Virginia | Charlottesville, Virginia 22908 |
| University of Alabama at Birmingham | Birmingham, Alabama 35294-3300 |
| Children's Hospital of Alabama | Birmingham, Alabama 35233 |
| Connecticut Children's Medical Center | Hartford, Connecticut 06106 |
| University of North Carolina | Chapel Hill, North Carolina 27599 |
| Duke University Medical Center | Durham, North Carolina 27710 |
| University of Florida | Gainesville, Florida 32610-0277 |
| Nemours Children's Clinic - Pensacola | Pensacola, Florida 32504 |
| Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids, Michigan 49503 |
| Yale University | New Haven, Connecticut 06520 |
| Wayne State University | Detroit, Michigan 48202 |
| Legacy Emanuel Children's Hospital | Portland, Oregon 97227 |
| BI-LO Charities Children's Cancer Center | Greenville, South Carolina 29605 |
| Albany Medical Center | Albany, New York 12208 |
| University of Texas Southwestern Medical Center | Dallas, Texas |
| University of Kentucky | Lexington, Kentucky 40536-0098 |
| Oregon Health and Science University | Portland, Oregon 97201 |
| Virginia Commonwealth University | Richmond, Virginia |
| Florida Hospital | Orlando, Florida 32803 |
| Memorial Health University Medical Center | Savannah, Georgia 31404 |
| University of Chicago Comprehensive Cancer Center | Chicago, Illinois 60637-1470 |
| M D Anderson Cancer Center | Houston, Texas 77030 |
| Seattle Children's Hospital | Seattle, Washington 98105 |
| Wake Forest University Health Sciences | Winston-Salem, North Carolina 27157 |
| Childrens Memorial Hospital | Chicago, Illinois 60614 |
| Lombardi Comprehensive Cancer Center at Georgetown University | Washington, District of Columbia 20057 |
| M D Anderson Cancer Center- Orlando | Orlando, Florida 32806 |
| University of Hawaii | Honolulu, Hawaii 96813 |
| Saint Luke's Mountain States Tumor Institute | Boise, Idaho 83712 |
| Saint Vincent Hospital and Health Services | Indianapolis, Indiana 46260 |
| Saint John Hospital and Medical Center | Detroit, Michigan 48236 |
| Kalamazoo Center for Medical Studies | Kalamazoo, Michigan 49008 |
| Saint John's Mercy Medical Center | Saint Louis, Missouri 63141 |
| Nevada Cancer Research Foundation CCOP | Las Vegas, Nevada 89106 |
| Saint Barnabas Medical Center | Livingston, New Jersey 07039 |
| New York University Langone Medical Center | New York, New York 10016 |
| Columbia University Medical Center | New York, New York 10032 |
| State University of New York Upstate Medical University | Syracuse, New York 13210 |
| Saint Vincent Hospital | Green Bay, Wisconsin 54301 |
| University of Illinois | Chicago, Illinois 60612 |
| Cook Children's Medical Center | Fort Worth, Texas 76104 |
| Memorial Healthcare System - Joe DiMaggio Children's Hospital | Hollywood, Florida 33021 |
| West Virginia University Charleston | Charleston, West Virginia 25304 |
| The Children's Medical Center of Dayton | Dayton, Ohio 45404 |
| Advocate Lutheran General Hospital | Park Ridge, Illinois 60068 |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami, Florida 33136 |
| University of Minnesota Medical Center-Fairview | Minneapolis, Minnesota 55455 |
| C S Mott Children's Hospital | Ann Arbor, Michigan 48109 |
| Riley Hospital for Children | Indianapolis, Indiana 46202 |
| Miller Children's Hospital | Long Beach, California 90806 |
| Childrens Hospital of Orange County | Orange, California 92868-3874 |
| Alfred I duPont Hospital for Children | Wilmington, Delaware 19803 |
| Nemours Children's Clinic - Jacksonville | Jacksonville, Florida 32207-8426 |
| Nemours Childrens Clinic - Orlando | Orlando, Florida 32806 |
| Saint Joseph Children's Hospital of Tampa | Tampa, Florida 33607 |
| Children's Healthcare of Atlanta - Egleston | Atlanta, Georgia 30322 |
| The Childrens Mercy Hospital | Kansas City, Missouri 64108 |
| Rainbow Babies and Childrens Hospital | Cleveland, Ohio 44106 |
| Penn State Hershey Children's Hospital | Hershey, Pennsylvania 17033 |
| Palmetto Health Richland | Columbia, South Carolina 29203 |
| East Tennessee Childrens Hospital | Knoxville, Tennessee 37916 |
| Saint Joseph's Regional Medical Center | Paterson, New Jersey 07503 |
| Childrens Hospital-King's Daughters | Norfolk, Virginia 23507 |
| Children's Hospital Colorado | Aurora, Colorado 80045 |
| Floating Hospital for Children at Tufts Medical Center | Boston, Massachusetts 02111 |
| Lucile Packard Children's Hospital Stanford University | Palo Alto, California 94304 |
| University of California San Francisco Medical Center-Parnassus | San Francisco, California 94143 |
| Raymond Blank Children's Hospital | Des Moines, Iowa 50309 |
| Children's Hospital-Main Campus | New Orleans, Louisiana 70118 |
| The Toledo Hospital/Toledo Children's Hospital | Toledo, Ohio 43606 |
| Saint Christopher's Hospital for Children | Philadelphia, Pennsylvania 19134 |
| Greenville Cancer Treatment Center | Greenville, South Carolina 29605 |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls, South Dakota 57117-5134 |
| Providence Sacred Heart Medical Center and Children's Hospital | Spokane, Washington 99204 |
