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Compromised Microcirculation in Women With Polycystic Ovary Syndrome


N/A
18 Years
35 Years
Open (Enrolling)
Female
Polycystic Ovary Syndrome

Thank you

Trial Information

Compromised Microcirculation in Women With Polycystic Ovary Syndrome


In these studies, we propose to use the skin as a relatively non-invasive model to examine
cardiovascular and endothelial function in obese women with and without PCOS. Data have
indicated an important role for testosterone in influencing the peripheral microcirculation.
While testosterone can lead to vasodilation in the peripheral microcirculation in both men
and in women without PCOS, testosterone appears to induce vasoconstriction in women with
PCOS. The differential response between women with and without PCOS, and between men and
women may be the result of differential ET-1 actions in the vessel, and regulated by the
receptor subtype is involved in these actions.


Inclusion Criteria:



- Obese women (18-35) years with and without PCOS

Exclusion Criteria:

- Conditions that would preclude safe use of hormones

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Outcome Measure:

Skin blood flow and cutaneous vascular conductance

Outcome Time Frame:

6 non consecutive days

Safety Issue:

No

Principal Investigator

Nina Stachenfeld, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

John B. Pierce Laboratory

Authority:

United States: Institutional Review Board

Study ID:

0801003437

NCT ID:

NCT00757185

Start Date:

February 2008

Completion Date:

December 2012

Related Keywords:

  • Polycystic Ovary Syndrome
  • skin blood flow
  • microcirculation
  • Polycystic Ovary Syndrome

Name

Location
John B. Pierce Laboratory New Haven, Connecticut  06520