BLI850-302: BLI850 vs an Approved Active Control Bowel Preparation in Adult Subjects Undergoing Colonoscopy

Inclusion Criteria:

1. Male or female outpatients who are undergoing colonoscopy for a routinely accepted
indication, including:

- Evaluation of barium enema results

- GI bleeding

- Anemia of unknown etiology

- Neoplastic disease surveillance

- Abnormal Endosonography

- Inflammatory bowel disease

- Unknown diarrhea or constipation etiology

- Polypectomy

- Laser therapy

- Routine screening

2. At least 18 years of age.

3. Otherwise in good health, as determined by physical exam and medical history.

4. If female, and of child-bearing potential, is using an acceptable form of birth
control (hormonal birth control, IUD, double-barrier method, depot contraceptive,
abstinent, or vasectomized spouse).

5. Negative urine pregnancy test at screening, if applicable.

6. In the Investigator's judgment, subject is mentally competent to provide informed
consent to participate in the study.

Exclusion Criteria:

1. Subjects with known or suspected ileus, severe ulcerative colitis, gastrointestinal
obstruction, gastric retention, bowel perforation, toxic colitis, or megacolon.

2. Subjects with impaired consciousness that predisposes them to pulmonary aspiration.

3. Subjects who are undergoing colonoscopy for foreign body removal or decompression.

4. Subjects with clinically significant electrolyte abnormalities based on Visit 1
laboratory results.

5. Subjects who had previous significant gastrointestinal surgeries (e.g. colostomy,
colectomy, gastric bypass).

6. Subjects who are pregnant or lactating, or intending to become pregnant during the
study.

7. Subjects of childbearing potential who refuse a pregnancy test.

8. Subjects who are allergic to any preparation components

9. Subjects who, in the opinion of the Investigator, should not be included in the study
for any reason, including inability to follow study procedures.

10. Subjects who have participated in an investigational surgical, drug, or device study
within the past 30 days.