Phase II Randomized Trial of Fulvestrant With or Without Dasatinib in Men and Postmenopausal Women Who Have Hormone Receptor-positive Advanced Breast Cancer Previously Treated With an Aromatase Inhibitor

Inclusion Criteria:

- Histologically confirmed hormone receptor positive (HR+) [(estrogen receptor (ER+)
and/or progesterone receptors(PgR+)] breast cancer according to immunohistochemistry
(IHC)

- Measureable or evaluable-only disease

- human epidermal growth factor receptor 2+ (HER2+) or HER2- breast cancer

- Males and females ≥18 years of age

- Females are post menopausal or surgically sterile

- Recurrent or progressive advanced breast cancer (locally-advanced or metastatic),
that has progressed: (a) during or within 12 months after completion of adjuvant
Aromatase Inhibitor (AI) treatment OR (b) during AI treatment in advanced setting
(metastatic therapy)

Exclusion Criteria:

- Pregnant or breast feeding

- >1 chemotherapy regimen for advanced disease

- Pleural or pericardial effusion

- Serious cardiac condition