Inclusion Criteria

Inclusion Criteria

- Subjects with CIMF (including post ET/PV MF) requiring therapy, including:

- Eastern Cooperative Oncology Group (ECOG) performance status 0-2

- Men of reproductive potential who can agree to practice effective contraception
during the entire study period and for one month after the last study treatment

- Women of child-bearing potential who have a negative pregnancy test within 14 days
prior to the first dose of study drug and can agree to practice effective
contraception during the entire study period and for one month after the last study
treatment, unless documentation of infertility exists

- Subjects who are able to understand and willing to sign the informed consent form

Exclusion Criteria

- Subjects with uncontrolled inter-current illness including, but not limited to,
ongoing active infection, symptomatic congestive heart failure, unstable angina
pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would
limit compliance with study requirements as judged by treating physician. Subjects
receiving antibiotics for infections that are under control may be included in the
study unless the antibiotic is a CYP3A4 inducer/inhibitor

- Subjects known to be HIV-positive

- Subjects with known active hepatitis A, B, or C, or latent hepatitis B

- Women who are pregnant or lactating

- Subjects with prior radiation therapy to more than 20% of the hematopoietic marrow
(prior radiation to spleen is allowed)