Inclusion Criteria

Eligibility criteria

Inclusion criteria:

- Histologically documented adenocarcinoma of the breast

- ANC > 1000 cells

- Female; age > 18

- Zubrod PS 0-1

- Platelets > 100,000

- Stage IIA-IIIB disease

- Total bilirubin < 1.5 ULN

- No evidence of any metastatic disease

- Serum Creatinine < 1.5 gm/dl

- No prior systemic therapy for breast cancer or Creat Cl > 30 ml/min

- Not pregnant or lactating

- Serum ALT < 2.0 ULN

- ER, PR and HER2 status required

- LVEF (MUGA/echo WNL)

- No baseline > 2 neuropathy

- Urine protein: creat ratio < 1.0

- HER2-negative - either IHC 0-1+ or FISH ratio < 2.0

- Hemoglobin > 9 gm/dl

- (FISH testing is required for all HER2 2-3+ tumors by IHC)

Exclusion criteria:

- No Histologically documented adenocarcinoma of the breast

- No-ANC > 1000 cells

- Female; age < 18

- Zubrod PS > 0-1

- Platelets < 100,000

- Stage IV disease

- Total bilirubin > 1.5 ULN

- metastatic disease

- Serum Creatinine > 1.5 gm/dl

- prior systemic therapy for breast cancer or Creat Cl > 30 ml/min

- pregnant or lactating

- Serum ALT > 2.0 ULN baseline > 2 neuropathy

- Urine protein: creat ratio >1.0

- HER2-positive

- Hemoglobin < 9 gm/dl