Inclusion Criteria

Criteria:

- Healthy adult participants meeting the following criteria:

- Limit cruciferous vegetables to no more than one serving each week for about 6 weeks

- Limit resveratrol-containing foods (i.e., wine, peanuts, mulberries, grapes,
cranberries, blueberries, and huckleberries) to no more than one serving each per day
for about 6 weeks

- No caffeine-containing food or beverages (e.g., coffee, colas, chocolate, or
over-the-counter medications) or food items that have been reported to affect
drug/carcinogen metabolizing enzymes (e.g., grapefruit, grapefruit juice, cruciferous
vegetables, and food cooked over charcoal) beginning 72 hours before and until 8
hours after each set of CYP probe drug administration

- Leukocytes >= 3,000/uL

- Absolute neutrophil count >= 1,500/uL

- Platelet count >= 100,000/uL

- Total bilirubin =< 2.0 mg/dL

- AST/ALT =< 1.5 times upper limit of normal (ULN)

- Creatinine =< ULN

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- Must have a resting systolic blood pressure >= 100 mm Hg at screening and prior to
probe drug administration

- Must not consume more than three drinks of alcohol per week on average

- No prior invasive cancers (i.e., non-skin cancer) within the past 5 years

- No history of allergic reactions to resveratrol-containing products or CYP probe
drugs (e.g, caffeine, dextromethorphan, losartan, or buspirone)

- No uncontrolled intercurrent illness including, but not limited to, any of the
following:

- Ongoing or active infection

- Symptomatic congestive heart failure

- Unstable angina pectoris

- Cardiac arrhythmia

- Psychiatric illness or social situation that would limit compliance with study
requirements

- No over-the-counter medications beginning 72 hours before and until 8 hours after
each CYP probe drug administration

- No participation in another clinical intervention trial within the past 3 months

- No concurrent medications or supplements that are known CYP enzyme inducers or
inhibitors

- No concurrent herbal medicines, dietary supplements, or above-standard vitamins or
minerals (a standard daily multivitamin or mineral supplement is acceptable)

- Non-smoking, defined as not currently smoking or stopped smoking more than 1 year ago

- Normal liver and renal function

- Able and willing to adhere to the following dietary restrictions:

- ECOG performance status (PS) 0-1 OR Karnofsky PS 70-100%