Inclusion Criteria:

- Participants must provide written, voluntary informed consent to participate in the
study.

- Participants must be naive to antiretroviral treatment with HIV RNA greater than or
equal to 1,000 copies/mL at screening, and in the investigator's opinion, require
antiretroviral therapy.

- Participant's vital signs, physical examination, and laboratory results must not
exhibit evidence of acute illness.

- Participant has not been treated for an active acquired immune deficiency syndrome
(AIDS)-defining opportunistic infection within 45 days of initiating study drug.
Participants who are on stable maintenance therapy for an opportunistic infection may
be enrolled after consultation with the Sponsor.

- Participant does not require and agrees not to take any drugs that are
contraindicated or have significant pharmacokinetic interactions with study drugs
during the course of the study. Participant agrees not to take any medication during
the study, including over-the-counter medicines, vitamins, minerals, herbal
preparations, alcohol, or recreational drugs without the knowledge and permission of
the principal investigator.

- Female participants must be either postmenopausal for at least one year, surgically
sterile, or must use a non-hormonal method of birth control that is acceptable to
both the participant and investigator. All female participants must have a urine
pregnancy test performed at screening visit and on Day minus 1/baseline, and results
of both tests must be negative. Female participants may not be breastfeeding.

- Participants have received no prior treatment with an HIV-1 integrase inhibitor.

Exclusion Criteria:

- Participants must not have history of an allergic reaction or significant sensitivity
to the study drugs.

- Participants may not have an ongoing history of substance abuse or psychiatric
illness that could preclude protocol adherence.

- Participant cannot have resistance to lopinavir/ritonavir, tenofovir, or
emtricitabine based on the HIV-1 drug resistance genotypic test results at the
screening visit.

- Participant may not have significant medical history of concomitant illness or
disease that would adversely affect his/her participating in the study.

- Participants may not have received any investigational drug or investigational
vaccine within 30 days prior to study drug administration.

- Participants may not have any of the following abnormal screening results:
Hemoglobin <= 8.0 grams/deciliter, absolute neutrophil count <= 750 cells/microliter,
Platelet count <= 50,000 per milliliter, alanine aminotransferase (ALT) (serum
glutamic-pyruvic transaminase [SGPT]) or aspartate aminotransferase (AST) (serum
glutamic oxaloacetic transaminase [SGOT]) >= 3.0 x upper limit of normal (ULN),
calculated creatinine clearance < 50 milliliter/minute, hepatitis B surface antigen
(HBsAg) is positive.

- The investigator considers the participant to be an unsuitable candidate for the
study.