Inclusion Criteria:

- Histologically confirmed solid tumor or lymphoma that is appropriate for treatment
with irinotecan.

- 18 years or older

- ECOG performance status 0-1

- Life expectancy of greater than 12 weeks.

- Normal organ and marrow function as defined below:

- leukocytes ≥ 3,000/μl

- absolute neutrophil count ≥ 1,500/μl

- platelets ≥ 100,000/μl

- total bilirubin within normal institutional limits

- AST(SGOT)/ALT(SGPT) ≤ 2.5 X institutional ULN (≤5 X ULN in patients with hepatic
metastases)

- creatinine within normal institutional limits OR

- glomerular filtration rate ≥50 ml/min/1.73 m2 for patients with creatinine
levels above institutional normal as calculated by the modified MDRD equation
recommended by the National Kidney Disease Education Program

- Measurable or assessable disease.

- Able to understand and the willing to sign a written informed consent document.

- Women of child-bearing potential and men and their partners must agree to use
adequate contraception (hormonal or barrier method of birth control) prior to study
entry and for the duration of study participation.

- Patients with UGT1A1 genotype 6/6, 6/7, and 7/7. Patients with either one or two of
the rare alleles (i.e., 5 allele and 8 allele), and carriers of the *6 allele will
not be enrolled in the study. Patients will have blood drawn for genotyping upon
signing the informed consent form for this study.

- Patients taking any statin therapy should interrupt the dosing of the statin for the
3 days before and after the administration of irinotecan at each cycle

Exclusion Criteria:

- Biologic therapy, chemotherapy, radiotherapy, or investigational agent within 4 weeks
(6 weeks for nitrosoureas or mitomycin C) prior to entering the study.

- Cannot be receiving any other investigational agents.

- Use of colony growth factor within 3 week prior to study entry.

- Post-transplant patients, as they may be subject to severe neutropenia.

- Uncontrolled brain metastases. Patients with brain metastases must have stable
neurologic status off of steroids and anticonvulsants for at least 4 weeks and must
be without neurologic dysfunction that would confound the evaluation of neurologic
and other adverse events.

- Uncontrolled intercurrent illness including, but not limited to ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements.

- Pregnant women are excluded from this study because irinotecan is an agent with the
potential for teratogenic or abortifacient effects. Breastfeeding should be stopped.

- HIV-positive patients, as patients with immune deficiency are at increased risk of
lethal infections when treated with marrow-suppressive therapy.

- History of inflammatory bowel disease requiring therapy or patients with chronic
diarrhea syndromes or paralytic ileus.

- Patients who have undergone a major surgical procedure, open biopsy or significant
traumatic injury within 28 days prior to start of therapy cannot participate.

- Patients with prior pelvic irradiation cannot participate.