An Open-Label, Multiple-Dose, Dose-Escalation Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of the MEK Inhibitor GSK1120212 in Subjects With Solid Tumors or Lymphoma

Inclusion Criteria:

Part 1

- Written informed consent provided.

- 18 years old or older.

- Histologically or cytologically confirmed diagnosis of solid tumor malignancy or
lymphoma that is not responsive to standard therapies or for which there is no
approved or curative therapy.

- Performance Status score of 0 or 1 according to the Eastern Cooperative Oncology
Group (ECOG) scale.

- Able to swallow and retain oral medication.

- Male subjects must agree to use one of the contraception methods listed. This
criterion must be followed from the time of the first dose of study medication until
four weeks after the last dose of study medication. However, the Sponsor advises
that contraception be used for a total of 16 weeks following the last dose (based on
the lifecycle of sperm).

- A female subject is eligible to participate if she is of:

- Non-childbearing potential defined as pre-menopausal females with a documented
tubal ligation or hysterectomy; or postmenopausal defined as 12 months of
spontaneous amenorrhea [in questionable cases a blood sample with simultaneous
follicle stimulating hormone (FSH) > 40 MlU/mL and estradiol < 40 pg/mL (<140
pmol/L) is confirmatory]. Females on hormone replacement therapy (HRT) and
whose menopausal status is in doubt will be required to use one of the
contraception methods in Section 8.1 if they wish to continue their HRT during
the study. Otherwise, they must discontinue HRT to allow confirmation of
post-menopausal status prior to study enrollment. For most forms of HRT, at
least two to four weeks will elapse between the cessation of therapy and the
blood draw; this interval depends on the type and dosage of HRT. Following
confirmation of their post-menopausal status, they can resume use of HRT during
the study without use of a contraceptive method.

- Child-bearing potential and agrees to use one of the contraception methods
listed in Section 8.1 for an appropriate period of time (as determined by the
product label or investigator) prior to the start of dosing to sufficiently
minimize the risk of pregnancy at that point. Female subjects must agree to use
contraception until four weeks after the last dose of study medication.

- Note: Oral contraceptives are not reliable due to potential drug-drug
interaction.

- CPP
- Adequate organ system function as defined in Table 9. Absolute neutrophil count
(ANC)>/= 1.0 X 109/L; Hemoglobin >/= 9 g/dL; Platelets >/= 75 X 109/L; PT/INR and PTT
in the presence of liver metastasis.); Creatinine clearance >/= 50 mL/min OR 24-hour urine creatinine clearance >/= 50 mL/min; Ejection
fraction >/= LLN by ECHO or MUGA.

Part 2 - As per Part 1 with the exception of criterion 3 and:

- Histologically or cytologically confirmed diagnosis of melanoma, pancreatic,
colorectal cancer (CRC), non-small cell lung cancer, or other tumor with BRAF
mutation.

- CRC must be KRAS or BRAF mutation positive.

- Subjects with melanoma, CRC, or non-small cell lung cancer must provide either the
results of a BRAF or KRAS mutation assay, archived tumor tissue, or a fresh biopsy.

- Subjects must be incurable or resistant to standard therapy.

Part 3 - As per Part 1 and:

- For the biopsy portion of the study, subjects must have accessible tumor for biopsy,
and willingness to provide pre- and post dose biopsies.

Exclusion Criteria:

- Currently receiving cancer therapy (chemotherapy, radiation therapy, immuno-therapy,
biologic therapy, hormonal therapy, surgery and/or tumor embolization).

- Use of an investigational anti-cancer drug within 28 days or five half-lives,
whichever is shorter, prior to the first dose of GSK1120212. A minimum of 10 days
between termination of the investigational drug and administration of GSK1120212 is
required. In addition, any drug-related toxicity should have recovered to Grade 1 or
less.

- Previous treatment with a MEK inhibitor. Subjects previously treated with a BRAF
inhibitor are eligible with approval of a GSK medical monitor.

- Current use of a prohibited medication or requires any of these medications during
treatment with GSK1120212.

- Current use of warfarin. NOTE: Low molecular weight heparin and prophylactic
low-dose warfarin are permitted. PT/PTT must meet the inclusion criteria. Subjects
taking warfarin must have their INR followed closely.

- Presence of active gastrointestinal disease or other condition that will interfere
significantly with the absorption, distribution, metabolism, or excretion of drugs.

- Any major surgery, radiotherapy, or immunotherapy within the last four weeks.
Chemotherapy regimens with delayed toxicity within the last four weeks (six weeks for
prior nitrosourea or mitomycin C). Chemotherapy regimens given continuously or on a
weekly basis with limited potential for delayed toxicity within the last two weeks.
Note: Use of erythropoietin replacement or bisphosphonates is considered supportive
care and their use is permitted.

- History of RVO or central serous retinopathy.

- Visible retinal pathology as assessed by ophthalmologic exam that is considered a
risk factor for retinal vein thrombosis or central serous retinopathy.

- Intraocular pressure > 21mm Hg as measured by tonography.

- Glaucoma diagnosed within one month prior to study Day 1.

- Psychological, familial, sociological, or geographical conditions that do not permit
compliance with the protocol.

- Concurrent condition that in the investigator's opinion would jeopardize compliance
with the protocol.

- Leptomeningeal metastases or spinal cord compression due to disease.

- Subjects with previously untreated brain metastases. Subjects with brain metastases
that were previously treated with gamma knife or whole brain radiation may enroll two
weeks or four weeks after treatment, respectively. These subjects must be
asymptomatic and either off corticosteroids or on a stable dose of corticosteroids
for at least one month prior to the first dose of GSK1120212. Subjects are not
permitted to receive enzyme inducing anti-epileptic drugs (EIAEDs) during the study.

- Primary malignancy of the central nervous system.

- Evidence of severe or uncontrolled systemic diseases (e.g., unstable or uncompensated
respiratory, hepatic, renal, or cardiac disease).

- Unresolved toxicity greater than common terminology criteria for adverse events
(CTCAE) Grade 1 from previous anti-cancer therapy except alopecia (if applicable)
unless agreed to by a GSK Medical Monitor and the investigator.

- QTc interval >/= 480 msecs.

- History of acute coronary syndromes (including unstable angina), coronary
angioplasty, or stenting within the past 24 weeks.

- Class II, III, or IV heart failure as defined by the New York Heart Association
(NYHA) functional classification system.

- Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs
chemically related to the study drug, dimethyl sulfoxide (DMSO), or excipients.

- Pregnant or lactating female.

- Unwillingness or inability to follow the procedures outlined in the protocol.