Late Effects of Proton Radiation Therapy in Patients With Low-Grade Glioma

Inclusion Criteria:

- Histologically confirmed low-grade gliomas, WHO classification II/IV or equivalent
low grade histology, including protoplasmic, fibrillary, gemistocytic astrocytomas,
and mixed variants such as oligoastrocytomas

- Must have at least one of: (1) progressive or recurrent disease as defined by
imaging, (2) persistence or progression of debilitating neurological symptoms, or (3)
at risk of early progression as defined by either (a) age of 40 or older or (b) MIB-1
of 3% or greater

- KPS of 70 or greater

- 18 years of age or older

- Surgical and medical/chemotherapeutic interventions are per physician's discretion
and are acceptable

- Must be able to speak and comprehend English

Exclusion Criteria:

- Other baseline neurocognitive or emotional disorders or deficits, including but not
limited to head injury, CVA, TIA, or other cerebral insults with residual
neuropsychiatric deficits, psychiatric disorders, learning disabilities, HIV
positivity or other medical conditions at high risk of causing neurocognitive decline
or emotional instability

- Prior history of cranial irradiation

- Pregnancy at the time of radiation treatment

- Unable to undergo MRI scans (e.g., embedded ferromagnetic metal or pacemakers)

- Comorbid illness or reason to suggest a life expectancy of less than 5 years