Omega 3 Fish Oil Supplements vs. Placebo for Patients With Non-alcoholic Steatohepatitis (NASH)

Inclusion Criteria:

1. NASH with NAS (NASH Activity Score) of >4 evident on a biopsy performed within 6
months of enrollment.

2. Age 21 years or older.

3. BMI 25 or greater.

4. Ability to provide informed consent.

Exclusion Criteria:

1. Cirrhosis evident clinically or on biopsy.

2. Secondary forms of NASH such as that seen with bariatric surgery or medication
induced from such medications as methotrexate, amiodarone, tamoxifen,
corticosteroids.

3. Current or past history of diabetes or hyperlipidemia requiring specific drug therapy
(see below).

4. Current use of a weight loss medicine, such as a 'fat-burner' or similar agent

5. Alcohol consumption > 30 g/day, currently or for more than 3 consecutive months
within 5 years.

6. Other liver disease (hepatitis C,B, Wilson's, autoimmune, ct-1-antitrypsin and
hemochromatosis or HIV

7. Pregnancy or unwillingness to use an effective form of birth control for women of
child bearing years.

8. Renal insufficiency (creatinine > 2), symptomatic coronary, peripheral or
neurovascular disease, symptomatic heart failure or advanced respiratory disease
requiring oxygen therapy.

9. Inability to provide informed consent.

10. Any condition in the opinion of the primary investigator that would contraindicate
the patient's participation.