A Phase III, Randomized, Double-Blind, Placebo-Controlled Multi-Center Study of ASA404 in Combination With Paclitaxel and Carboplatin as First-Line Treatment for Locally Advanced or Metastatic (Stage IIIb/IV) Non-Small Cell Lung Cancer (NSCLC)
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Overall survival rate
Patients will be followed every six weeks for survival following treatment completion, discontinuation, or documented disease progression until either death or the data cut off date.
No
Novartis Pharmaceuticals
Study Director
Novartis Pharmaceuticals
United States: Food and Drug Administration
CASA404A2301
NCT00662597
April 2008
May 2010
Name | Location |
---|---|
Akron City Hospital | Akron, Ohio 44304 |
Cedars Sinai Medical Center | Los Angeles, California 90048-1804 |
Loyola University Medical Center | Maywood, Illinois 60153 |
University Hospitals of Cleveland | Cleveland, Ohio 44106 |
Cancer Research Center of Hawaii | Honolulu, Hawaii 96813 |
University of Nebraska Medical Center | Omaha, Nebraska 68198-3330 |
Virginia Oncology Associates | Newport News, Virginia 23606 |
St. Agnes Cancer Center | Baltimore, Maryland 21229 |
Arlington Cancer Center | Arlington, Texas 76012 |
South Texas Cancer Institute | San Antonio, Texas 78229 |
Florida Cancer Specialists | Fort Myers, Florida 33901 |
Medical Oncology Hematology Associates, Inc. | Dayton, Ohio 45409 |
Moores UCSD Cancer Center | La Jolla, California 92093-0658 |
Arena Oncology Associates | Great Neck, New York 11021 |
St. John's Mercy Medical Center | Saint Louis, Missouri 63141 |
Highlands Oncology Group | Springdale, Arkansas 72764 |
Tyler Cancer Center | Tyler, Texas 75702 |
Genesis Cancer Center | Hot Springs, Arkansas 71913 |
Northwest Cancer Specialists | Vancouver, Washington 98664 |
Northern Utah Associates | Ogden, Utah 84403 |
Arizona Oncology Associates | Tucson, Arizona 85712-2254 |
Cancer Care Associates | Fresno, California 93720 |
California Cancer Care | Greenbrae, California 94904 |
UC Davis Comprehensive Cancer Center | Sacramento, California 95817 |
Virginia Cancer Institute | Richmond, Virginia 23230 |
Eastchester Center for Cancer Care | Bronx, New York 10469 |
Georgetown University Hospital | Washington, District of Columbia 20007 |
Hope Oncology | Richardson, Texas 75080 |
Texoma Cancer Center | Wichita Falls, Texas 76310 |
The West Clinic | Memphis, Tennessee 38120 |
Highline Medical Oncology | Burien, Washington 98166 |
New York Oncology Hematology | Albany, New York 12208 |
University of Arizona Cancer Center | Tucson, Arizona 85724 |
University of Wisconsin | Madison,, Wisconsin 53792-5666 |
Medical Consultants | Milwaukee, Wisconsin 53215-3690 |
Northwest Georgia Oncology Centers | Marietta, Georgia 30060 |
Billings Clinic | Billings, Montana 59107-7000 |
Deke Slayton Cancer Center | Webster, Texas 77589 |
Syracuse VA Medical Center | Syracuse, New York 13210 |
University of Oklahoma Health Science Center | Oklahoma City, Oklahoma 73104 |
Fallon Clinic | Worcester, Massachusetts 01605 |
Cancer Care Centers of South Texas | San Antonio, Texas 78229 |
Loma Linda University Cancer Center | Loma Linda, California 92354 |
Cancer Centers of Central Florida, PA | Leesburg, Florida 34788 |
Tennessee Oncology | Nashville, Tennessee 37203 |
Chattanooga Oncology Hematology Associates | Chattanooga, Tennessee 37404 |
Sletten Cancer Institute | Great Falls, Montana 59405 |
St. Louis University Cancer Center | St. Louis, Missouri 63110 |
Hematology Oncology Associates of Rockland | Nyack, New York 10960 |
University of Louisville - James Graham Brown Cancer Center | Louisville, Kentucky 40202 |
Hematology Oncology Specialists | Metairie, Louisiana 70006 |
University of South Alabama/Mitchell Cancer Institute | Mobile, Alabama 36604 |
Alta Bates Summit Medical Center | Berkeley, California 94704 |
Pacific Oncology and Hematology Association | Encinitas, California 92024 |
Ronald Yanagihara - Private Practice | Gilroy, California 95020 |
University of California Irvine Comprhensive Center | Orange, California 92868 |
Loma Linda Oncology Medical Group, Inc. | Redlands, California 92374 |
California Pacific Medical Research Institute | San Francisco, California 94115 |
Redwood Regional Cancer Center | Santa Rosa, California 95403 |
Palm Beach Institute of Hematology & Oncology | Boynton Beach, Florida 33435 |
Advanced Medical Specialties (ACORN) | Miami, Florida 33176 |
Kootenai Cancer Center (ACORN) | Couer D'Alene, Idaho 83814 |
Advocate Illinois Masonic Medical Center | Chicago, Illinois 60657 |
Illinois Oncology/Warren Billhartz Cancer Ctr. | Maryville, Illinois 62062 |
Hematology/Oncology of North Shore | Skokie, Illinois 60076 |
Loyola Cancer Care & Research Ctr. at Central Dupage Hospital | Winfield, Illinois 60190 |
Ft. Wayne Oncology and Hematology | Ft. Wayne, Indiana 46815 |
Siouxland Hematology-Oncology Assoc., LLC | Sioux City, Iowa 51101 |
Kansas City Cancer Center, Southwest | Overland Park, Kansas 66210 |
Louisiana State University Health Sciences Center - Feist-Weiller Cancer Center | Shreveport, Louisiana 71103 |
The Harry and Jeanette Weinberg Cancer Institute at Franklin Square/MedStar Health | Baltimore, Maryland 21237 |
Sinai Hospital of Baltimore - The Alvin & Lois Lapidus Cancer Institute | Baltimore, Maryland 21215-5271 |
Peninsula Regional Oncology and Hematology | Salisbury, Maryland 21801 |
Boston VA Healthcare System | Boston, Massachusetts 02130 |
Breslin Cancer Center | Lansing, Michigan 48910 |
Osteopathic Medical Oncology and Hematology PC | Woodhaven, Michigan 28183 |
St. Luke's Hospital - St Luke's Cancer Center | Duluth, Minnesota 55811 |
Kansas City Veterans Affair Medical Center | Kansas City, Missouri 64128 |
St. Louis Cancer and Breast Institute | St. Louis, Missouri 63141 |
Center for Cancer Care and Research (US Oncology) | St. Louis, Missouri 63141 |
Rochester General Hospital - Lipson Cancer Center | Rochester, New York 14621 |
Alamance Regional Medical Center-Cancer Ctr. | Burlington, North Carolina 27215 |
Carolina Cancer Mgmt/Cape Fear Valley Health System/Med Onc | Fayetteville, North Carolina 28304 |
Oncology Hematology Care Research | Cincinnati, Ohio 45242 |
Medical Oncology Hematology Associates, Inc. - Dayton Clinical Oncology Program | Dayton, Ohio 45429 |
Cleo Craig Memorial Cancer Ctr. & Research Clinic | Lawton, Oklahoma 73505 |
Kaiser Permanente, Northwest Region | Portland, Oregon 97227 |
Allegheny General Hospital/Allegheny Cancer Center | Pittsburg, Pennsylvania 15212 |
South Carolina Oncology Associate | Columbia, South Carolina 29210 |
Lowcountry Hematology & Oncology PA | Mt. Pleasant, South Carolina 29464 |
Texas Oncology Cancer Center of the High Plains | Amarillo, Texas 79106 |
Patient's Comprehensive Cancer Center | Carrolton, Texas 75010 |
Texas Oncology at Presbyterian Hospital | Dallas, Texas 75231 |
University of Texas Southwestern Medical Center/Simmons Comprehensive Cancer Center | Dallas, Texas 75390-9179 |
Texas Oncology at Garland | Garland, Texas 75042 |
UT Health Center | Tyler, Texas 75709 |
Danville Hematology & Oncology | Danville, Virginia 24541 |
Medical Oncology & Hematology Associates of Northern Virginia | Fairfax, Virginia 22031 |
Providence Everett Medical Center/Providence regional Cancer Partnership | Everett, Washington 98201 |
Medical College of Wisconsin/Division of Neoplastic & Related Disorders | Milwaukee, Wisconsin 53226 |