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Open Label Multi-Centric Phase II Study of the Raf Kinase Inhibitor BAY 43-9006 in Chronic Myelogenous Leukemia (CML) Patients Resistant to Gleevec (Imatinib)


Phase 2
18 Years
N/A
Not Enrolling
Both
Chronic Myelogenous Leukemia

Thank you

Trial Information

Open Label Multi-Centric Phase II Study of the Raf Kinase Inhibitor BAY 43-9006 in Chronic Myelogenous Leukemia (CML) Patients Resistant to Gleevec (Imatinib)


Inclusion Criteria:



- Have Philadelphia chromosome positive chronic myelogenous leukemia (CML) in chronic
phase, as per IBMTR criteria

- Have documented hematologic resistance to Gleevec (Imatinib) following a prior
hematologic response to Gleevec administered at doses of at least 400 mg/d for at
least 3 months.

- Have WBC >20 x 109/L at study entry

- Have an ECOG performance status. Status of 0, 1 or 2

- Have an anticipated survival of at least 16 weeks.

- Be able to comply with study procedures and follow-up examinations.

- Signed informed consent must be obtained prior to any study specific procedures.

Exclusion Criteria:

- Congestive heart failure > class II as defined by the New York Heart Association
Functional Classification (NYHA)

- Cardiac arrhythmias requiring antiarrythmics (excluding beta blockers or digoxin)

- Active coronary artery disease or ischemia

- History of HIV infection or chronic hepatitis B or C

- Active clinically serious infections (> grade 2 NCI-CTC)

- Patients with seizure disorder requiring anti-epileptic drugs

- History of solid organ allograft

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

To determine the major hematologic response rate (i.e. complete and partial hematologic responses) associated with BAY 43-9006 in patients with chronic phase CML resistant to Gleevec.

Outcome Time Frame:

Every 3 months

Safety Issue:

No

Principal Investigator

Bayer Study Director

Investigator Role:

Study Director

Investigator Affiliation:

Bayer

Authority:

United States: Food and Drug Administration

Study ID:

10941

NCT ID:

NCT00661180

Start Date:

January 2004

Completion Date:

February 2005

Related Keywords:

  • Chronic Myelogenous Leukemia
  • Leukemia
  • Leukemia, Myeloid
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Name

Location

Eugene, Oregon