Microvascular Perfusion Sonographic Imaging to Detect Early Stage Ovarian Cancer

Inclusion Criteria

DISEASE CHARACTERISTICS:

- Diagnosis of adnexal mass

- Scheduled to undergo surgical oophorectomy

PATIENT CHARACTERISTICS:

- Not pregnant or nursing

- Negative pregnancy test

- No known respiratory failure as manifested by signs and symptoms of carbon dioxide
retention or hypoxemia

- No pulmonary vasculitis

- No known history of severe emphysema

- No known history of pulmonary emboli

- No other condition that causes pulmonary hypertension due to compromised pulmonary
arterial vasculature

- No known history of severe pulmonary hypertension (i.e., systolic pulmonary artery
pressures > 90 mm Hg)

- No known history of congenital heart defect that creates a bidirectional or
right-to-left shunt

- No worsening or clinically unstable congestive heart failure

- No known acute myocardial infarction or acute coronary syndromes

- No known serious ventricular arrhythmias

- Not at high risk for arrhythmia due to prolongation of the QT interval

- No known or suspected hypersensitivity to blood, blood products, or albumin

- No known hypersensitivity to perflutren

- No known or suspected hypersensitivity to octafluoropropane or any other ingredients
of perflutren lipid microspheres (Definity®)

- No mental status problems, illiteracy, or other circumstance that would preclude
giving informed consent

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics