Inclusion Criteria:

All of the following inclusion criteria must be met prior to participation in this study

1. The patient must sign an informed consent. A signed consent form is required prior
to the performance of any protocol-related procedures or assessments.

2. The patient must be >= 18 years of age.

3. The patient must have progressive or recurrent carcinoma and has failed all standard
therapies for his/her tumor.

4. The patient must have a negative CT scan with contrast of the brain or MRI of the
brain within 45 days of enrollment.

5. The patient must be using an acceptable/effective method of contraception if she is a
female patient of childbearing potential.

6. The patient must have a negative serum pregnancy test within 14 days of entering the
protocol if she is a female of childbearing potential.

7. The patient must have an ECOG score <= 2.

8. The patient must be willing and able to abide by the protocol.

Exclusion Criteria:

None of the exclusion criteria may be met prior to patient participation in this study

1. The patient has a history of CHF, migraines, coagulopathy, stroke or inadequately
controlled hypertension.

2. The patient has asthma or symptomatic COPD.

3. The patient has autonomic nerve dysregulation syndrome.

4. The patient has angina or is taking nitrates or has had a MI within the past six
months.

5. The patient has a significant ventricular arrhythmia, class III or IV CHF or has a
known coronary stenoses >80% and has not undergone either angioplasty or CABG

6. The patient is taking phosphodiesterase inhibitors

7. The patient has malignant or poorly controlled hypertension (>160/100)

8. The patient has symptomatic orthostatic hypotension

9. The patient is taking arterial vasodilators such as nifedipine or amlodipine or alpha
blockers such as terazosin, tamsulosin and prazosin.

10. The patient has a screening absolute neutrophil count less than 1.5 K/uL

11. The patient has a screening platelet count less than 100 K/uL.

12. The patient has a screening creatinine greater than 2.0 mg/dL

13. The patient has a screening amino alanine transferase (ALT), or aspartate
aminotransferase (AST) > 2.5 times the upper limit of the laboratory reference range
or a total bilirubin > 1.0 mg/dL.

14. The patient has a known immunodeficiency disorder.

15. The patient is enrolled, or the patient plans to enroll, in any concurrent study of
another investigational product.

16. The patient is taking, or the patient is planning to take other cancer treatments
during the study except for patients with prostate cancer using LHRH agonist therapy.

17. The patient has a known hypersensitivity to any of the components of SPI 1620 or to
docetaxel.

18. The patient has previously failed treatment with docetaxel for his/her tumor and a
dose of SPI-1620 that has been shown to enhance tumor blood flow has not been
identified.

19. The patient does not have a tumor that is at least 1cm. -