Trial Information

Genetic Epidemiology of Adult Brain Tumors

Primary Objective:

The primary objective of this research is to establish a clinic-based case-control study for
examination of potential risk factors for primary adult brain tumors. After assembling a
series of 1,500 cases and 3,000 controls, investigators will test current hypotheses on
ge-netic and environmental risk factors for the occurrence of these tumors.

STUDY DESIGN:

In this case-control study, persons with a recent diagnosis (within 4 months) of a primary
brain tumor will be identified in the neurology/neurosurgery clinics at major treatment
referral centers in the Southeast. Non-blood related relatives (eg. in-laws), friends or
other persons will be recruited as controls. Names and contact information of eligible
controls will be ascertained from patients. A total of 1,500 cases and 3,000 controls will
be enrolled over the course of the 5-year study. All enrolled subjects will complete a one
hour interview on lifestyle, environmental exposures, diet, physical activity, tobacco use
and medical history. They will also be asked to provide a DNA sample, a water sample and a
toenail sample (from each great toe). At the end of data collection, lifestyles and genetic
attributes will be compared in cases and controls to identify any differences that may be
relevant to the causation of disease. Because the study will recruit patients near the time
of disease diagnosis, full enrollment should be possible. In addition, high re-sponse rates
are anticipated among the controls. Thus, with the large numbers of patients available and
high anticipated response rates, the study offers a unique opportunity to successfully
identify environmental and genetic risk factors for this uncommon form of cancer.