The Impact of Androgen Ablation Therapy on Cognitive Functioning and Functional Status in Men With Prostate Cancer Age 65 and Older

Inclusion Criteria is the same at both sites, and is outlined below:

Inclusion Criteria:

Comparison Androgen Ablation Group

1. Diagnosis of prostate cancer

2. Age 65 or older

3. Ability to converse, write and read English

4. Able to provide informed consent

5. Have been on continuous androgen ablation therapy for 6 months-3 years

Androgen Ablation Subgroup

1. Diagnosis of prostate cancer

2. Age 65 or older

3. Ability to converse, write and read English

4. Able to provide informed consent

5. Starting androgen ablation therapy

6. No androgen ablation therapy within the past year

No Androgen Ablation Subgroup

1. Diagnosis of prostate cancer

2. Age 65 or older

3. At least 1-year post definitive localized treatment

4. Ability to converse, write and read English

5. Able to provide informed consent

6. Not anticipated to start androgen ablation therapy

Exclusion Criteria:

All Groups

1. No history of androgen ablation therapy within past year

2. Previous or current treatment with chemotherapy

3. History of neurological brain damage

4. History of untreated psychiatric disease

5. Previous head traumas

6. Current use of opioids

7. History of developmental disorders

8. Current history of alcohol or substance abuse