Cardiac MRI for Assessment of Cardiac Structure and Function Following Doxorubicin Based Chemotherapy for Newly Diagnosed Non-Hodgkin's Lymphoma or Hodgkin's Lymphoma
N/A
19 Years
N/A
19 Years
N/A
Open (Enrolling)
Both
Cardiac Toxicity, Chemotherapeutic Agent Toxicity, Lymphoma
Both
Cardiac Toxicity, Chemotherapeutic Agent Toxicity, Lymphoma
Trial Information
Cardiac MRI for Assessment of Cardiac Structure and Function Following Doxorubicin Based Chemotherapy for Newly Diagnosed Non-Hodgkin's Lymphoma or Hodgkin's Lymphoma
OBJECTIVES:
- To determine whether early myocardial structural and functional changes can be detected
using cardiac MRI in patients with newly diagnosed non-Hodgkin lymphoma or Hodgkin
lymphoma receiving doxorubicin hydrochloride-based chemotherapy.
OUTLINE: Patients undergo cardiac MRI with gadolinium contrast prior to initiation of
doxorubicin hydrochloride-based chemotherapy and 3 months after completion of six courses of
chemotherapy for non-Hodgkin lymphoma and twelve courses of chemotherapy for Hodgkin
lymphoma.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of non-Hodgkin lymphoma or Hodgkin lymphoma
- Newly diagnosed disease
- Planning to receive doxorubicin hydrochloride-based chemotherapy solely at the
University of Nebraska Medical Center
PATIENT CHARACTERISTICS:
- Not pregnant or nursing
- Fertile patients must use effective contraception
- No pacemaker
- No chronic kidney disease stages 3-5 (glomerular filtration rate < 60 mL/min)
- Able to lie flat for 90 minutes
- No metallic foreign body not approved for MRI
- No known hypersensitivity to gadolinium contrast or other required drugs in the study
- No comorbidity or condition which, in the opinion of the investigator, may interfere
with the assessments and procedures of this study
- Able to fulfill the requirements of the study
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No prior chemotherapy
- No prior radiotherapy to mantle or mediastinum
Type of Study:
Interventional
Study Design:
Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Diagnostic
Outcome Measure:
Change in myocardial function and structure
Outcome Time Frame:
cMRI will be done prior to induction of doxorubicin based chemotherapy and at three months after completion of the doxorubicin based chemotherapy regimen.
Safety Issue:
No
Principal Investigator
Thomas R. Porter, M.D.
Investigator Role:
Principal Investigator
Investigator Affiliation:
University of Nebraska
Authority:
United States: Institutional Review Board
Study ID:
409-07
NCT ID:
NCT00577798
Start Date:
November 2007
Completion Date:
Related Keywords:
- Cardiac Toxicity
- Chemotherapeutic Agent Toxicity
- Lymphoma
- chemotherapeutic agent toxicity
- cardiac toxicity
- stage I adult Hodgkin lymphoma
- stage II adult Hodgkin lymphoma
- stage III adult Hodgkin lymphoma
- stage IV adult Hodgkin lymphoma
- stage I adult T-cell leukemia/lymphoma
- stage II adult T-cell leukemia/lymphoma
- stage III adult T-cell leukemia/lymphoma
- stage IV adult T-cell leukemia/lymphoma
- anaplastic large cell lymphoma
- angioimmunoblastic T-cell lymphoma
- cutaneous B-cell non-Hodgkin lymphoma
- stage I mycosis fungoides/Sezary syndrome
- stage II mycosis fungoides/Sezary syndrome
- stage III mycosis fungoides/Sezary syndrome
- stage IV mycosis fungoides/Sezary syndrome
- stage I cutaneous T-cell non-Hodgkin lymphoma
- stage II cutaneous T-cell non-Hodgkin lymphoma
- stage III cutaneous T-cell non-Hodgkin lymphoma
- stage IV cutaneous T-cell non-Hodgkin lymphoma
- adult grade III lymphomatoid granulomatosis
- adult nasal type extranodal NK/T-cell lymphoma
- Waldenstrom macroglobulinemia
- contiguous stage II adult Burkitt lymphoma
- noncontiguous stage II adult Burkitt lymphoma
- stage I adult Burkitt lymphoma
- stage III adult Burkitt lymphoma
- stage IV adult Burkitt lymphoma
- contiguous stage II adult diffuse large cell lymphoma
- noncontiguous stage II adult diffuse large cell lymphoma
- stage I adult diffuse large cell lymphoma
- stage III adult diffuse large cell lymphoma
- stage IV adult diffuse large cell lymphoma
- contiguous stage II adult diffuse mixed cell lymphoma
- noncontiguous stage II adult diffuse mixed cell lymphoma
- stage I adult diffuse mixed cell lymphoma
- stage III adult diffuse mixed cell lymphoma
- stage IV adult diffuse mixed cell lymphoma
- contiguous stage II adult diffuse small cleaved cell lymphoma
- noncontiguous stage II adult diffuse small cleaved cell lymphoma
- stage I adult diffuse small cleaved cell lymphoma
- stage III adult diffuse small cleaved cell lymphoma
- stage IV adult diffuse small cleaved cell lymphoma
- contiguous stage II adult immunoblastic large cell lymphoma
- noncontiguous stage II adult immunoblastic large cell lymphoma
- stage I adult immunoblastic large cell lymphoma
- stage III adult immunoblastic large cell lymphoma
- stage IV adult immunoblastic large cell lymphoma
- contiguous stage II adult lymphoblastic lymphoma
- noncontiguous stage II adult lymphoblastic lymphoma
- stage I adult lymphoblastic lymphoma
- stage III adult lymphoblastic lymphoma
- stage IV adult lymphoblastic lymphoma
- contiguous stage II grade 1 follicular lymphoma
- noncontiguous stage II grade 1 follicular lymphoma
- stage I grade 1 follicular lymphoma
- stage III grade 1 follicular lymphoma
- stage IV grade 1 follicular lymphoma
- contiguous stage II grade 2 follicular lymphoma
- noncontiguous stage II grade 2 follicular lymphoma
- stage I grade 2 follicular lymphoma
- stage III grade 2 follicular lymphoma
- stage IV grade 2 follicular lymphoma
- contiguous stage II grade 3 follicular lymphoma
- noncontiguous stage II grade 3 follicular lymphoma
- stage I grade 3 follicular lymphoma
- stage III grade 3 follicular lymphoma
- stage IV grade 3 follicular lymphoma
- contiguous stage II mantle cell lymphoma
- noncontiguous stage II mantle cell lymphoma
- stage I mantle cell lymphoma
- stage III mantle cell lymphoma
- stage IV mantle cell lymphoma
- extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
- nodal marginal zone B-cell lymphoma
- splenic marginal zone lymphoma
- contiguous stage II marginal zone lymphoma
- noncontiguous stage II marginal zone lymphoma
- stage I marginal zone lymphoma
- stage III marginal zone lymphoma
- stage IV marginal zone lymphoma
- contiguous stage II small lymphocytic lymphoma
- noncontiguous stage II small lymphocytic lymphoma
- stage I small lymphocytic lymphoma
- stage III small lymphocytic lymphoma
- stage IV small lymphocytic lymphoma
- Hodgkin Disease
- Lymphoma
- Lymphoma, Non-Hodgkin
- Lymphoma, Large-Cell, Immunoblastic
Name | Location |
|---|---|
| UNMC Eppley Cancer Center at the University of Nebraska Medical Center | Omaha, Nebraska 68198-7680 |
