Inclusion Criteria:

- Any subject with presumed or known potentially resectable NSCLC

- Due to the nature of NSCLC, children (<18 year of age) will not be considered

- Men, women, and minorities

- Subjects must be able to safely undergo conscious sedation for the EUS procedure

- Subjects must be surgical candidates

- Subjects must not have an uncorrectable coagulopathy and must be able to refrain from
the used of aspirin one week prior to the EUS

- Patient must provide signed written informed consent

Exclusion Criteria:

- Subjects with a history of previously treated lung, head & neck, or esophageal cancer
are not eligible if the histologic cell type is determined to be the same as what is
biopsied during the EUS-FNA

- Uncorrectable coagulopathy

- Significant co-morbidities such as uncontrolled heart failure, or severe chronic
obstructive pulmonary disease (COPD) that would limit their survivability to surgery

- Evidence of significant active infection (e.g. pneumonia, peritonitis, wound abscess)

- Evidence of serious ongoing illness such as uncontrolled metabolic disease (diabetes
mellitus, hypothyroidism, etc.) or cardiac condition

- Evidence of dementia or altered mental status that would prohibit the giving and
understanding of informed consent, and no evidence of psychiatric illness that would
preclude adequate compliance with this protocol