Inclusion Criteria:

- History of histologically documented MM previously enrolled on UARK 98-026 with
relapsed or progressive disease after at least one autologous transplant.

- Patient has measurable disease in which to capture response, defined as:

- Serum M-protein level > 1.0 gm/dl (10.0 g/L) measured by serum protein
electrophoresis or immunoglobulin electrophoresis

- Urinary M-protein excretion > 200 mg/24 hrs

- Bone marrow plasmacytosis of > 30percent by bone marrow aspirate and/or biopsy

- Serum Free Light Chains (By the Freelite test) > 10 mg/dL with an abnormal
kappa/lambda ration.

- 50percent increase in size of lytic and/or focal lesions or development of new
lesions recognized by radiographic studies.

- Performance status of 2 as per SWOG scale, unless PS of 3-4 based solely on bone
pain.

- Patients must have a platelet count 50,000/mm3, unless the low platelet count is due
to documented (>30 percent) extensive myeloma infiltration of the bone marrow.

- Patients must have adequate renal function defined as serum creatinine < 2.5 mg/dl.

- Patients must have adequate hepatic function defined as serum transaminases and
direct bilirubin < 2 x the upper limit of normal.

- Pregnant or nursing women may not participate. Women of childbearing potential must
have a negative pregnancy documented within one week of registration. Women of
reproductive potential may not participate unless they have agreed to use an
effective contraceptive method.

- Male or female adults of at least 18 years of age.

- Patients must have signed and IRB-approved written informed consent form and
demonstrate willingness to meet follow-up schedule and study procedure obligations

- > 5 x 106 CD34 cells/kg in storage strongly desired, but not mandated

Exclusion Criteria:

- Not previously enrolled on UARK 98-026.

- Has received salvage therapy after coming off UARK 98-026.

- Evidence of POEMS Syndrome..

- Significant neurotoxicity interfering with ADL.

- Platelet count < 50,000/mm3

- Clinically significant hepatic dysfunction as noted by bilirubin or AST >3 times the
upper normal limit or clinically significant concurrent hepatitis.

- New York Hospital Association (NYHA) Class III or Class IV heart failure.

- Myocardial infarction within the last 6 months.

- Truly non-secretory MM (no increase in serum free-light chains) in the absence of
bone marrow plasmacytosis and MRI-defined focal lesions with CT-FNA-proven MM

- Uncontrolled, active infection requiring IV antibiotics.

- Patients with a history of treatment for clinically significant ventricular cardiac
arrhythmias.

- Poorly controlled hypertension, diabetes mellitus, or other serious or psychiatric
illness that could potentially interfere with the completion of treatment according
to this protocol.

- Pregnant or potential for pregnancy. Women of childbearing potential will have a
pregnancy test at screening, and will be required to use a medically approved
contraceptive method. Pregnancy testing will be performed prior to administration of
each dose of study drug.

- Breast-feeding women may not participate.