Inclusion Criteria:

1. Histologically or cytologically confirmed squamous cell carcinoma or adenocarcinoma
of the esophagus. Stage T2-T3, N any, M0 (no evidence of disseminated cancer except
regional involvement which may be designated as "M1a"). No evidence of metastatic
disease

2. Medically able to tolerate major abdominal and/or thoracic surgery

3. Able to undergo EUS procedure and pass EUS probe through esophageal lumen

4. Able to receive concurrent systemic chemotherapy (cisplatin and 5-FU) and RT

5. Clinical management plan includes esophagectomy after completion of two courses of
chemoradiation therapy

6. Karnofsky Performance Status of ≥ 60

7. Minimum life expectancy of 4 months

8. Hematologic function

- Absolute neutrophil count (ANC) ≥ 1500/mm3

- Platelet count ≥ 100,000/mm3

- Hemoglobin ≥ 9 g/dL

9. Hepatic function:

- Total bilirubin < 1.5 X upper limit of normal (ULN)

- AST and ALT < 3 X ULN

- Albumin ≥ 3.0 g/dL or ≥ 2.0 g/dL if the lower level is considered by the
investigator to be due to nutritional depletion

10. Serum creatinine < 1.5 mg/dL and/or creatinine clearance ≥ 65 mL/min

11. ≥ 18 years old

12. If female, must be non-pregnant, nonlactating, of non-childbearing potential, or
using adequate birth control

13. Capable of understanding and agreeing to fulfill the requirements of the protocol

14. Sign the IRB/EC approved consent form

Exclusion Criteria:

1. History of anaphylaxis to planned CT contrast agent

2. Prior esophageal stent insertion, laser, or photodynamic therapy

3. Prior chest RT or major esophageal surgery

4. Any prior receipt of cytotoxic chemotherapeutic agents

5. Prior receipt of other cancer treatments (ie, Chelation therapy), vaccines, or
biological response modifiers/growth factors (ie, GM-CSF, IL-2) within the past 4
weeks.

6. Prior malignancy unless disease free for ≥ 3 years. Note: basal cell/squamous
carcinoma of the skin, in situ cervical or breast carcinoma, or superficial
transitional cell bladder carcinoma will be allowed. Subjects with a history of low
risk prostatic carcinoma (ie, clinical stage 1 or 2a, Gleason score < or = 6 and PSA
<10 ng/mL at diagnosis) will be allowed

7. Significant currently active systemic diseases including uncontrolled diabetes,
severe heart disease (New York Heart Association Class III or IV), uncontrolled
hypertension, myocardial infarction within 3 months, severe bronchial obstruction,
uncontrolled seizure disorder, or peripheral neuropathy greater than CTCAE grade 1

8. Allergies to any of the active or inactive components of OncoGel (ie, allergies to
degradable PLGA [poly(lactide-co-glycolide) sutures])

9. Receipt of an investigational drug or device within 30 days prior to signing
informed consent

10. Any medical condition or other circumstance that, in the Investigator's opinion,
would prevent completion of the study, interfere with analysis of the study results,
or potentially adversely affect subject safety

11. Known esophageal varices