Inclusion Criteria:

- Subject is male and at least 18 years of age.

- Subject has histologically- or cytologically-confirmed prostate adenocarcinoma with
metastatic, progressive disease while on androgen deprivation therapy.

- Subject has radiograph-documented (computed tomography, magnetic resonance imaging or
x-ray) metastatic disease.

- Subject has undergone orchiectomy or is expected to continue receiving luteinizing
hormone-releasing hormone analogue therapy, and has a testosterone level of <50 ng/dL
at screening.

- Subject has discontinued all antiandrogen therapy (within 30 days for flutamide and
within 6 weeks for all others) prior to their first dose of study drug.

- Subject has a prostate-specific antigen level ≥5 ng/mL.

- Subject meets all screening laboratory values as specified in the protocol.

- Subject has a screening ejection fraction that is above the lower limit of the
institutional normal range.

- Subject has ECOG performance status of 0 to 2.

- Subject has normal or, in the opinion of the investigator, clinically insignificant,
physical examination findings, ECG and chest x-ray results.

- Subjects, even if surgically sterilized (ie, status postvasectomy), who: agree to
practice effective barrier contraception during the entire study treatment period and
for 4 months after the last dose of study drug, or agree to completely abstain from
heterosexual intercourse.

Exclusion Criteria:

- Subject has known hypersensitivity to TAK-700 or related compounds.

- Subject has received prior therapy with aminoglutethimide or ketoconazole within 30
days prior to the first dose of study drug.

- Subject has received prior chemotherapy for prostate cancer.

- Subject has received any investigational compound within 30 days prior to first dose
of study drug.

- Subject has received prior herbal product known to decrease prostate-specific antigen
levels (eg, Saw Palmetto, PC-SPES) within 30 days prior to the first dose of study
drug.

- Subject has received radiation therapy for prostate cancer within 30 days prior to
first dose of study drug.

- Chronic therapy with oral or other systemically administered corticosteroids, such as
prednisone, within 30 days prior to Screening. Chronic therapy is defined as the use
of corticosteroids for more than 7 days within a 30-day period.

- Subject has current spinal cord compression, current bilateral hydronephrosis, or
current bladder neck outlet obstruction.

- Subject has a history of adrenal insufficiency.

- Subject has a history of myocardial infarction, ischaemic symptomatic heart disease,
cardiac arrhythmias or thromboembolic events (eg, deep vein thrombosis, pulmonary
embolism, or symptomatic cerebrovascular events), or any other cardiac condition
(e.g., pericardial effusion restrictive cardiomyopathy) within 12 months prior to
first dose of study drug.

- Subject has any symptoms which the investigator deems related to prostate cancer,
i.e., bone pain, pelvic pain.

- Subject has a history of congestive heart failure (New York Heart Association Class
II or greater.

- Subject has history of another malignancy other than basal cell carcinoma or state 1
squamous cell carcinoma of the skin, within the last 5 years.

- Subject has uncontrolled hypertension.

- Subject is known to have HIV infection, chronic Hepatitis B or C or any other serious
medical condition or psychiatric illness that might affect life expectancy or make it
difficult to successfully manage and follow the subject according to protocol.

- Subject is unable to understand verbal or written English or any other language for
which a certified translation of the institutional review board (IRB)-approved
informed consent has been provided.

- Subject is unwilling or unable to comply with the protocol or cooperate fully with
the investigator and site personnel.