A Phase III Randomized Controlled Clinical Trial of Carboplatin and Paclitaxel (or Gemcitabine) Alone or in Combination With Bevacizumab (NSC #704865, IND #113912) Followed by Bevacizumab and Secondary Cytoreductive Surgery in Platinum-Sensitive, Recurrent Ovarian, Peritoneal Primary and Fallopian Tube Cancer. NCI-Supplied Agents: Bevacizumab (NSC #704865, IND #113912)
PRIMARY OBJECTIVES:
I. To determine if surgical secondary cytoreduction in addition to adjuvant chemotherapy
increases the duration of overall survival in patients with recurrent platinum sensitive
epithelial ovarian cancer, peritoneal primary or fallopian tube cancer.
II. To determine if the addition of bevacizumab to the second-line and maintenance phases of
treatment increases the duration of overall survival relative to second-line paclitaxel and
carboplatin alone in patients with recurrent platinum sensitive epithelial ovarian cancer,
peritoneal primary or fallopian tube cancer.
SECOND OBJECTIVES:
I. To determine if the addition of bevacizumab to the second-line and maintenance phase of
treatment increases the duration of progression-free survival relative to second-line
paclitaxel and carboplatin alone in patients with recurrent platinum sensitive epithelial
ovarian cancer, peritoneal primary or Fallopian tube cancer.
II. To prospectively determine the incidence of carboplatin and paclitaxel hypersensitivity
in these patients undergoing retreatment with both agents as first recurrence therapy.
III. To determine if surgical secondary cytoreduction in addition to adjuvant chemotherapy
increases quality of life (QOL) of patients with recurrent platinum-sensitive ovarian
epithelial cancer or primary peritoneal cavity cancer, as measured by the FACT-O trial
outcome index and Rand SF-36 physical functioning scale.
IV. To determine if the addition of bevacizumab to the second-line and maintenance phases of
treatment increases QOL relative to second-line paclitaxel and carboplatin alone in patients
with recurrent platinum-sensitive ovarian epithelial cancer or primary peritoneal cavity
cancer.
OUTLINE: This is a multicenter study. Patients are assigned to 1 of 4 treatment groups.
Patients who are not candidates for surgical cytoreduction (i.e., those for whom complete
cytoreduction in the estimation of the investigator is impossible or a medical infirmity
precludes exploration and debulking) are eligible to receive chemotherapy after
randomization.
Patients who are eligible for surgery undergo abdominal exploration with cytoreduction and
undergo tumor tissue collection and complete a quality of life questionnaire before and
after surgery. All patients are then randomized to 1 of 4 treatment arms.
ARM I: Patients receive paclitaxel intravenously (IV) over 3 hours or docetaxel IV over 1
hour and carboplatin IV over 60 minutes on day 1.
ARM II: Patients receive chemotherapy as in arm I and bevacizumab IV over 30-90 minutes on
day 1.
ARM III: Patients receive gemcitabine IV over 60 minutes on days 1and 8 and carboplatin as
in arm I.
ARM IV: Patients receive gemcitabine IV as in arm III, bevacizumab IV and carboplatin IV as
in arm II.
In all arms, treatment repeats every 21 days in the absence of disease progression or
unacceptable toxicity.
Patients with measurable disease achieving a clinical response (CR) receive 6-8 courses of
therapy. Patients with stable disease or partial regression receive a maximum of 6 courses.
Patients without measurable lesions as determined by a computed tomography (CT) scan prior
to initiating study treatment continue therapy for 6 courses or, if CA-125 normalizes, for 2
cycles beyond CA-125 normalization, whichever is greater. Patients in arm II then receive a
maintenance regimen comprising bevacizumab IV over 30-90 minutes. Treatment with bevacizumab
alone repeats every 3 weeks in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed periodically for 10 years.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Overall survival
Up to 10 years
No
Robert Coleman
Principal Investigator
Gynecologic Oncology Group
United States: Food and Drug Administration
NCI-2009-00587
NCT00565851
December 2007
Name | Location |
---|---|
Memorial Sloan Kettering Cancer Center | New York, New York 10021 |
Cleveland Clinic Foundation | Cleveland, Ohio 44195 |
University of Iowa Hospitals and Clinics | Iowa City, Iowa 52242 |
University of Mississippi Medical Center | Jackson, Mississippi 39216-4505 |
Washington University School of Medicine | Saint Louis, Missouri 63110 |
Abington Memorial Hospital | Abington, Pennsylvania 19001 |
Fox Chase Cancer Center | Philadelphia, Pennsylvania 19111 |
University of Washington Medical Center | Seattle, Washington 98195-6043 |
Tacoma General Hospital | Tacoma, Washington 98405 |
Hurley Medical Center | Flint, Michigan 48503 |
Pennsylvania Hospital | Philadelphia, Pennsylvania 19107 |
Boulder Community Hospital | Boulder, Colorado 80301-9019 |
Porter Adventist Hospital | Denver, Colorado 80210 |
Rose Medical Center | Denver, Colorado 80220 |
Swedish Medical Center | Englewood, Colorado 80110 |
Sky Ridge Medical Center | Lone Tree, Colorado 80124 |
North Suburban Medical Center | Thornton, Colorado 80229 |
Bronson Methodist Hospital | Kalamazoo, Michigan 49007 |
West Michigan Cancer Center | Kalamazoo, Michigan 49007-3731 |
Borgess Medical Center | Kalamazooaa, Michigan 49001 |
Fairview Ridges Hospital | Burnsville, Minnesota 55337 |
Hutchinson Area Health Care | Hutchinson, Minnesota 55350 |
United Hospital | St. Paul, Minnesota 55102 |
Ridgeview Medical Center | Waconia, Minnesota 55387 |
Geisinger Medical Center | Danville, Pennsylvania 17822-0001 |
Abramson Cancer Center of the University of Pennsylvania | Philadelphia, Pennsylvania 19104-4283 |
Avera Cancer Institute | Sioux Falls, South Dakota 57105 |
Morristown Memorial Hospital | Morristown, New Jersey 07962-1956 |
Henry Ford Hospital | Detroit, Michigan 48202 |
Memorial Hospital of South Bend | South Bend, Indiana 46601 |
Akron General Medical Center | Akron, Ohio 44302 |
Lehigh Valley Hospital | Allentown, Pennsylvania 18103 |
Reading Hospital and Medical Center | Reading, Pennsylvania 19612-6052 |
University of Texas Medical Branch | Galveston, Texas 77555-1329 |
LDS Hospital | Salt Lake City, Utah 84143 |
Rush University Medical Center | Chicago, Illinois 60612-3824 |
North Shore University Hospital | Manhasset, New York 11030 |
Brooke Army Medical Center | Fort Sam Houston, Texas 78234-6200 |
Hartford Hospital | Hartford, Connecticut 06102-5037 |
Franklin Square Hospital Center | Baltimore, Maryland 21237 |
Providence Alaska Medical Center | Anchorage, Alaska 99508 |
William Beaumont Hospital | Royal Oak, Michigan 48073 |
Cancer Institute of New Jersey | New Brunswick, New Jersey 08901 |
Via Christi Regional Medical Center | Wichita, Kansas 67214 |
Carolinas Medical Center | Charlotte, North Carolina 28232-2861 |
University of Oklahoma Health Sciences Center | Oklahoma City, Oklahoma 73104 |
Iowa Methodist Medical Center | Des Moines, Iowa 50309 |
Iowa Lutheran Hospital | Des Moines, Iowa 50316-2301 |
Group Health Cooperative | Seattle, Washington 98112 |
University of Wisconsin Hospital and Clinics | Madison, Wisconsin 53792-0001 |
MetroHealth Medical Center | Cleveland, Ohio 44109 |
Long Island Jewish Medical Center | New Hyde Park, New York 11040 |
Mount Sinai Medical Center | New York, New York 10029 |
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium | Seattle, Washington 98109 |
North Colorado Medical Center | Greeley, Colorado 80631 |
McKee Medical Center | Loveland, Colorado 80539 |
Cancer Center of Kansas - Chanute | Chanute, Kansas 66720 |
Cancer Center of Kansas - Dodge City | Dodge City, Kansas 67801 |
Cancer Center of Kansas - Newton | Newton, Kansas 67114 |
Cancer Center of Kansas - Salina | Salina, Kansas 67042 |
Cancer Center of Kansas - Wellington | Wellington, Kansas 67152 |
Associates in Womens Health | Wichita, Kansas 67203 |
Cancer Center of Kansas - Winfield | Winfield, Kansas 67156 |
Munson Medical Center | Traverse City, Michigan 49684 |
McKay-Dee Hospital Center | Ogden, Utah 84403 |
Cancer Care Northwest - Spokane South | Spokane, Washington 99202 |
University of New Mexico Cancer Center | Albuquerque, New Mexico 87131-5636 |
Methodist Estabrook Cancer Center | Omaha, Nebraska 68114-4199 |
Elkhart General Hospital | Elkhart, Indiana 46515 |
South Bend Clinic | South Bend, Indiana 46617 |
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center | Columbus, Ohio 43210-1240 |
Beebe Medical Center | Lewes, Delaware 19958 |
Mecosta County Medical Center | Big Rapids, Michigan 49307 |
Exempla Lutheran Medical Center | Wheat Ridge, Colorado 80033 |
Mercy Hospital | Coon Rapids, Minnesota 55433 |
Medical Oncology and Hematology Associates | Des Moines, Iowa 50309 |
Saint Joseph Mercy Hospital | Ann Arbor, Michigan 48106 |
Fairview-Southdale Hospital | Edina, Minnesota 55435 |
Abbott-Northwestern Hospital | Minneapolis, Minnesota 55407 |
Regions Hospital | Saint Paul, Minnesota 55101 |
Saint Francis Regional Medical Center | Shakopee, Minnesota 55379 |
Rice Memorial Hospital | Willmar, Minnesota 56201 |
Geisinger Medical Group | State College, Pennsylvania 16801 |
Northeast Georgia Medical Center | Gainesville, Georgia 30501 |
Miami Valley Hospital | Dayton, Ohio 45409 |
Cancer Center of Kansas - Fort Scott | Fort Scott, Kansas 66701 |
Cancer Center of Kansas-Independence | Independence, Kansas 67301 |
Research Medical Center | Kansas City, Missouri 64132 |
Saint Luke's East - Lee's Summit | Lee's Summit, Missouri 64086 |
Wenatchee Valley Medical Center | Wenatchee, Washington 98801-2028 |
Woman's Hospital | Baton Rouge, Louisiana 70815 |
Seattle Cancer Care Alliance | Seattle, Washington 98109 |
Longmont United Hospital | Longmont, Colorado 80501 |
Temple University Hospital | Philadelphia, Pennsylvania 19140 |
Genesys Regional Medical Center | Grand Blanc, Michigan 48439-8066 |
Singing River Hospital | Pascagoula, Mississippi 39581 |
Methodist Hospital | Houston, Texas 77030 |
Aurora Sinai Medical Center | Milwaukee, Wisconsin 53201-0342 |
Greater Baltimore Medical Center | Baltimore, Maryland 21204 |
Union Hospital of Cecil County | Elkton MD, Maryland 21921 |
Presbyterian Hospital | Charlotte, North Carolina 28233-3549 |
Pacific Gynecology Specialists | Seattle, Washington 98104 |
Washington Hospital Center | Washington, District of Columbia 20010 |
Memorial Medical Center | Springfield, Illinois 62781 |
Metro Health Hospital | Grand Rapids, Michigan 49506 |
University of Virginia | Charlottesville, Virginia 22908 |
University of North Carolina | Chapel Hill, North Carolina 27599 |
Duke University Medical Center | Durham, North Carolina 27710 |
Providence Medical Center | Kansas City, Kansas 66112 |
Northwestern University | Chicago, Illinois 60611 |
Hennepin County Medical Center | Minneapolis, Minnesota |
Saint Louis University Hospital | St. Louis, Missouri 63110-0250 |
Saint Alphonsus Regional Medical Center | Boise, Idaho 83706 |
Case Western Reserve University | Cleveland, Ohio 44106 |
Wayne State University | Detroit, Michigan 48202 |
Riverside Methodist Hospital | Columbus, Ohio 43214 |
Indiana University Medical Center | Indianapolis, Indiana 46202 |
Presbyterian - Saint Lukes Medical Center - Health One | Denver, Colorado 80218 |
University of Texas Southwestern Medical Center | Dallas, Texas |
Wichita CCOP | Wichita, Kansas 67214-3882 |
Northwest Hospital | Seattle, Washington 98133 |
Huntsman Cancer Institute/University of Utah | Salt Lake City, Utah 84112 |
Metro-Minnesota CCOP | St. Louis Park, Minnesota |
Lakeview Hospital | Stillwater, Minnesota 55082 |
Oregon Health and Science University | Portland, Oregon 97201 |
Florida Gynecologic Oncology | Fort Myers, Florida 33901 |
Jersey Shore Medical Center | Neptune, New Jersey 07754 |
Virginia Commonwealth University | Richmond, Virginia |
Providence Saint Joseph Medical Center | Burbank, California 91505-4866 |
Memorial Health University Medical Center | Savannah, Georgia 31404 |
Hillcrest Hospital Cancer Center | Mayfield Heights, Ohio 44124 |
Harrison Medical Center | Bremerton, Washington 98310 |
University of Chicago Comprehensive Cancer Center | Chicago, Illinois 60637-1470 |
M D Anderson Cancer Center | Houston, Texas 77030 |
Northern Indiana Cancer Research Consortium | South Bend, Indiana |
University of Cincinnati | Cincinnati, Ohio 45267-0502 |
Penn State Milton S Hershey Medical Center | Hershey, Pennsylvania 17033 |
The Community Hospital | Munster, Indiana 46321 |
Littleton Adventist Hospital | Littleton, Colorado 80122 |
Parker Adventist Hospital | Parker, Colorado 80138 |
New Ulm Medical Center | New Ulm, Minnesota 56073 |
Froedtert and the Medical College of Wisconsin | Milwaukee, Wisconsin 53226 |
Wake Forest University Health Sciences | Winston-Salem, North Carolina 27157 |
University of California San Francisco Medical Center-Mount Zion | San Francisco, California 94115 |
The Medical Center of Aurora | Aurora, Colorado 80012 |
Penrose-Saint Francis Healthcare | Colorado Springs, Colorado 80907 |
Saint Anthony Central Hospital | Denver, Colorado 80204 |
Exempla Saint Joseph Hospital | Denver, Colorado 80218 |
Colorado Cancer Research Program CCOP | Denver, Colorado 80224-2522 |
Saint Mary's Hospital and Regional Medical Center | Grand Junction, Colorado 81502 |
Saint Mary Corwin Medical Center | Pueblo, Colorado 81004 |
Saint Francis Hospital and Medical Center | Hartford, Connecticut 06105 |
The Hospital of Central Connecticut | New Britain, Connecticut 06050 |
John B Amos Cancer Center | Columbus, Georgia 31904 |
Iowa Oncology Research Association CCOP | Des Moines, Iowa 50309 |
Mercy Medical Center - Des Moines | Des Moines, Iowa 50314 |
Medical Oncology and Hematology Associates-Des Moines | Des Moines, Iowa 50309 |
Cancer Center of Kansas - El Dorado | El Dorado, Kansas 67042 |
Cancer Center of Kansas-Kingman | Kingman, Kansas 67068 |
Cancer Center of Kansas - Parsons | Parsons, Kansas 67357 |
Cancer Center of Kansas - Pratt | Pratt, Kansas 67124 |
Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita, Kansas 67208 |
Cancer Center of Kansas - Main Office | Wichita, Kansas 67214 |
Michigan Cancer Research Consortium Community Clinical Oncology Program | Ann Arbor, Michigan 48106 |
Oakwood Hospital | Dearborn, Michigan 48123 |
Saint John Hospital and Medical Center | Detroit, Michigan 48236 |
Grand Rapids Clinical Oncology Program | Grand Rapids, Michigan 49503 |
Saint Mary's Health Care | Grand Rapids, Michigan 49503 |
Spectrum Health at Butterworth Campus | Grand Rapids, Michigan 49503 |
Allegiance Health | Jackson, Michigan 49201 |
Sparrow Hospital | Lansing, Michigan 48912 |
Saint Mary Mercy Hospital | Livonia, Michigan 48154 |
Mercy Health Partners-Mercy Campus | Muskegon, Michigan 49443 |
Mercy Health Partners-Hackley Campus | Muskegon, Michigan 49442 |
Saint Joseph Mercy Oakland | Pontiac, Michigan 48341-2985 |
Saint Joseph Mercy Port Huron | Port Huron, Michigan 48060 |
Saint Mary's of Michigan | Saginaw, Michigan 48601 |
Lakeland Hospital | St. Joseph, Michigan 49085 |
Saint John Macomb-Oakland Hospital | Warren, Michigan 48093 |
Saint Luke's Hospital of Duluth | Duluth, Minnesota 55805 |
Unity Hospital | Fridley, Minnesota 55432 |
Saint John's Hospital - Healtheast | Maplewood, Minnesota 55109 |
Minnesota Oncology Hematology PA-Maplewood | Maplewood, Minnesota 55109 |
North Memorial Medical Health Center | Robbinsdale, Minnesota 55422 |
Park Nicollet Clinic - Saint Louis Park | Saint Louis Park, Minnesota 55416 |
Minnesota Oncology and Hematology PA-Woodbury | Woodbury, Minnesota 55125 |
Saint Luke's Cancer Institute | Kansas City, Missouri 64111 |
Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield | Springfield, Missouri 65802 |
Saint John's Hospital | Springfield, Missouri 65804 |
Cox Medical Center | Springfield, Missouri 65807 |
Cooper Hospital University Medical Center | Camden, New Jersey 08103 |
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County | Mount Holly, New Jersey 08060 |
Memorial Medical Center - Las Cruces | Las Cruces, New Mexico 88011 |
New York University Langone Medical Center | New York, New York 10016 |
Columbia University Medical Center | New York, New York 10032 |
State University of New York Upstate Medical University | Syracuse, New York 13210 |
Alamance Regional Medical Center | Burlington, North Carolina 27216 |
Aultman Health Foundation | Canton, Ohio 44710 |
Kettering Medical Center | Kettering, Ohio 45429 |
Northwest Cancer Specialists-Rose Quarter Cancer Center | Portland, Oregon 97227 |
Saint Luke's Hospital | Bethlehem, Pennsylvania 18015 |
Geisinger Wyoming Valley | Wilkes-Barre, Pennsylvania 18711 |
Sanford Cancer Center-Oncology Clinic | Sioux Falls, South Dakota 57104 |
The Don and Sybil Harrington Cancer Center | Amarillo, Texas 79106 |
Harrison Bremerton Hematology and Oncology | Bremerton, Washington 98310 |
Swedish Medical Center-First Hill | Seattle, Washington 98122-4307 |
Saint Joseph Medical Center | Tacoma, Washington 98405 |
Saint Vincent Hospital | Green Bay, Wisconsin 54301 |
Green Bay Oncology Limited at Saint Mary's Hospital | Green Bay, Wisconsin 54303 |
Green Bay Oncology at Saint Vincent Hospital | Green Bay, Wisconsin 54301-3526 |
Bay Area Medical Center | Marinette, Wisconsin 54143 |
Aspirus Regional Cancer Center | Wausau, Wisconsin 54401 |
University of California Medical Center At Irvine-Orange Campus | Orange, California 92868 |
Cancer Care Associates-Yale | Tulsa, Oklahoma 74136-1929 |
Women and Infants Hospital | Providence, Rhode Island 02905 |
Lake University Ireland Cancer Center | Mentor, Ohio 44060 |
Women's Cancer Associates | Saint Petersburg, Florida 33701 |
University of Illinois | Chicago, Illinois 60612 |
Stony Brook University Medical Center | Stony Brook, New York 11794 |
Elkhart Clinic | Elkhart, Indiana 46515 |
John Muir Medical Center-Concord Campus | Concord, California 94520 |
University of Colorado Cancer Center - Anschutz Cancer Pavilion | Aurora, Colorado 80045 |
Michiana Hematology Oncology PC-Elkhart | Elkhart, Indiana 46514 |
Michiana Hematology Oncology PC-Plymouth | Plymouth, Indiana 46563 |
Michiana Hematology Oncology PC-South Bend | South Bend, Indiana 46601 |
Michiana Hematology Oncology-PC Westville | Westville, Indiana 46391 |
Cancer Center of Kansas-Liberal | Liberal, Kansas 67901 |
University of Michigan University Hospital | Ann Arbor, Michigan 48109 |
Michiana Hematology Oncology PC-Niles | Niles, Michigan 49120 |
University of Missouri - Ellis Fischel | Columbia, Missouri 65203 |
Moses Cone Health System-Regional Cancer Center | Greensboro, North Carolina 27403 |
Duke Raleigh Hospital | Raleigh, North Carolina 27609 |
Utah Valley Regional Medical Center | Provo, Utah 84603 |
Dixie Medical Center Regional Cancer Center | Saint George, Utah 84770 |
Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan, Wisconsin 53081 |
Vince Lombardi Cancer Clinic | Two Rivers, Wisconsin 54241 |
Gynecologic Oncology of West Michigan PLLC | Grand Rapids, Michigan 49546 |
Center of Hope at Renown Medical Center | Reno, Nevada 89502 |
State University of New York Downstate Medical Center | Brooklyn, New York 11203 |
Monter Cancer Center | Lake Success, New York 11042 |
Black Hills Obstetrics and Gynecology | Rapid City, South Dakota 57701 |
Carilion Clinic Gynecological Oncology | Roanoke, Virginia 24016 |
Aurora Women's Pavilion of Aurora West Allis Medical Center | West Allis, Wisconsin 53227 |
Long Beach Memorial Medical Center-Todd Cancer Institute | Long Beach, California 90806 |
Kaiser Permanente Medical Care Program - Los Angeles Medical Center & Sunset Hospital | Los Angeles, California 90027 |
Kaiser Permanente Los Angeles Medical Center | Los Angeles, California 90027 |
Rocky Mountain Gynecologic Oncology PC | Englewood, Colorado 80110 |
Saint Dominic-Jackson Memorial Hospital | Jackson, Mississippi 39216 |
Southwest Gynecologic Oncology Associates Inc | Albuquerque, New Mexico 87106 |
Women's Cancer Center of Nevada | Las Vegas, Nevada 89109 |
Saint Luke's South Hospital | Overland Park, Kansas 66213 |
Kansas City CCOP | Prairie Village, Kansas 66208 |
Spectrum Health Reed City Hospital | Reed City, Michigan 49677 |
Providence Regional Cancer Partnership | Everett, Washington 98201 |
Gundersen Lutheran | La Crosse, Wisconsin 54601 |
Stanford University Hospitals and Clinics | Stanford, California 94305 |
Gynecologic Oncology Group of Arizona | Phoenix, Arizona 85012 |
Palo Alto Medical Foundation-Gynecologic Oncology | Mountain View, California 94040 |
Sudarshan K Sharma MD Limted-Gynecologic Oncology | Hinsdale, Illinois 60521 |
Saint Vincent Oncology Center | Indianapolis, Indiana 46260 |
University of Massachusetts Memorial Health Care | Worcester, Massachusetts 01605 |
The Women's Institute for Gynecologic Cancer and Special Pelvic Surgery | Phillipsburg, New Jersey 08865 |
University Medical Center Brackenridge | Austin, Texas 78701 |
PeaceHealth Medical Group PC | Bellingham, Washington 98226 |
Skagit Valley Hospital Regional Cancer Care Center | Mount Vernon, Washington 98274 |
Olympic Medical Cancer Care Center | Sequim, Washington 98384 |
Rockwood Cancer Treatment Center | Spokane, Washington 99204 |
Providence Saint Mary Regional Cancer Center | Walla Walla, Washington 99362 |
Cancer Institutes of Washington PLLC | Yakima, Washington 98902 |
Aurora Saint Luke's Medical Center | Milwaukee, Wisconsin 53215 |
Georgia Health Sciences University | Augusta, Georgia 30912 |
Jonsson Comprehensive Cancer Center | Los Angeles, California 90095 |
Carle Foundation - Carle Cancer Center | Urbana, Illinois 61801 |
Michiana Hematology Oncology PC-Mishawaka | Mishawaka, Indiana 46545-1470 |
Marie Yeager Cancer Center | Saint Joseph, Michigan 49085 |
Summa Akron City Hospital | Akron, Ohio 44304 |
Gynecologic Oncology Group | Philadelphia, Pennsylvania 19103 |
Sanford USD Medical Center - Sioux Falls | Sioux Falls, South Dakota 57117-5134 |
Geisinger Medical Center-Cancer Center Hazelton | Hazleton, Pennsylvania 18201 |
Community Howard Regional Health | Kokomo, Indiana 46904 |
Indiana University Health La Porte Hospital | La Porte, Indiana 46350 |
Saint Joseph Regional Medical Center-Mishawaka | Mishawaka, Indiana 46545-1470 |
Christiana Care Health System-Christiana Hospital | Newark, Delaware 19718 |
Bronson Battle Creek | Battle Creek, Michigan 49017 |
Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland, Ohio 44111 |
Women's Cancer Care Associates LLC | Albany, New York 12208 |
Fletcher Allen Health Care-Medical Center | Burlington, Vermont 05401 |
Harrison Poulsbo Hematology and Oncology | Poulsbo, Washington 98370 |