18F-FACBC PET-CT for the Detection and Staging of Recurrent Prostate Carcinoma (CA129356-01).

STUDY NOW CLOSED for recruitment

Inclusion Criteria:

- Patients must be 18 years of age or older.

- Patients will have been originally diagnosed with localized (Stage T1c, T2, or T3 )
prostate carcinoma and have undergone what was considered definitive therapy for
localized disease.

- In the case of brachytherapy, cryotherapy, or external beam radiation, treatment will
have occurred at least 2 years in the past to eliminate patients with so-called "PSA
bump."

- Patient will have suspicion of recurrent prostate carcinoma as defined by: ASTRO
criteria of three consecutive rises of PSA or earlier if clinically appropriate,
and/or nadir + 2.0 after radiotherapy, and/or greater than 0.3 after prostatectomy.

- Ability to lie still for PET scanning

- Patients must be able to provide written informed consent.

Exclusion Criteria:

- Age less than 18.

- Greater than T3 disease in past

- Prior prostatectomy or 2 years since brachytherapy, cryotherapy, or external beam
radiation therapy.

- Does not meet above criteria of suspicious PSA elevation

- Inability to lie still for PET scanning

- Cannot provide written informed consent.

- Bone scan findings characteristic for metastatic prostate carcinoma

- Less than 2 months since any prior prostate biopsy (to decrease false positive uptake
from inflammation).