A Phase I Study of Dasatinib With Bortezomib (VelcadeĀ®) and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
Key
Interventional
Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Maximum Tolerated Dose (MTD) and Recommended MTD of Dasatinib in Combination With Bortezomib and Dexamethasone
MTD is defined as the dose level combination below the dose level that produces a dose-limiting toxicity in at least 2 out of 6 or fewer participants in that cohort. If MTD is not reached, the recommended MTD is the maximum dose that the participants received.
Days 1 to 21
Yes
Bristol-Myers Squibb
Study Director
Bristol-Myers Squibb
United States: Food and Drug Administration
CA180-181
NCT00560352
February 2008
February 2011
Name | Location |
---|---|
Winship Cancer Institute, Emory University | Atlanta, Georgia 30322 |
Orlando Health, Inc. M.D. Anderson Cancer Center Orlando | Orlando, Florida 32806 |