Inclusion Criteria:

- Patient must comply with follow-up evaluations

- Patient or representative must provide informed consent prior to enrollment

- Patient scheduled for elective surgical excision of the left, anterior or low
anterior colon

- Patient must meet all criteria and be eligible to have open or laparoscopic
colorectal surgery with primary anastomosis at one location

Exclusion Criteria:

- Crohns disease

- Emergency colorectal surgery for trauma, obstruction, ischemic bowel, perforated
diverticulum and all other emergent diagnosis.

- Patients who have not had mechanical bowel preparation

- Patients with known documented sensitivity/allergy to bovine material

- Severe radiation damage to tissue

- Carcinomatosis or stage IV cancer

- BMI is 35 or greater

- Cancer at primary anastomosis site that cannot be excised

- Patients who require an ileo rectal anastomosis

- Surgery anticipated to include jejunostomy pouch

- Anticipated diverting stoma

- No anti adhesive barrier can be used around anastomotic site

- No multiple circular anastomosis

- Surgeons discretion to exclude any patient he/she feels would not have a safe
anastomosis

- Patient life expectacny less than follow-up timeframe of study

- Pregnancy

- Patients currently enrolled in a study that competes for the same patient population