Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically or cytologically confirmed non-small cell lung cancer (NSCLC) meeting
1 of the following criteria:

- Unresectable stage IIIB disease with pleural effusion or pericardial effusion

- Stage IIIB disease that was treated with chemotherapy alone as first-line
therapy

- Stage IV disease

- Must have documented progression of disease after receiving one cytotoxic
chemotherapy regimen for metastatic disease

- At least one lesion that is bidimensionally measurable by CT scan or MRI

- Must have evaluable disease outside the radiation field

- New lesions that develop within the radiation field are allowed

- Measurable disease status as defined by RECIST criteria

- Brain metastases allowed provided they have been previously treated and are
controlled

PATIENT CHARACTERISTICS:

Inclusion criteria:

- ECOG performance status 0-2

- ANC > 1,000/mm³

- Hemoglobin > 8.0 g/dL

- Platelet count > 75,000/mm³

- Creatinine < 2.0 times upper limit of normal (ULN)

- AST and ALT < 5 times ULN

- Total bilirubin < 2.5 times ULN

- Prior malignancy allowed provided the patient's life expectancy is best defined by
the diagnosis of NSCLC

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for up to 4 weeks after
completion of study therapy

Exclusion criteria:

- Peripheral neuropathy ≥ 2

- Severe allergic reaction to prior vinca alkaloid treatment

- Active or uncontrolled infection

- Significant history of uncontrolled cardiac disease, including any of the following:

- Uncontrolled hypertension

- Unstable angina

- Myocardial infarction within the past 6 months

- Uncontrolled congestive heart failure

- Cardiomyopathy with decreased ejection fraction

- Severe reaction to prior monoclonal antibody therapy

PRIOR CONCURRENT THERAPY:

Inclusion criteria:

- See Disease Characteristics

- Prior oral tyrosine kinase inhibitor therapy (e.g. gefitinib or erlotinib) allowed

- Not considered cytotoxic therapy for study eligibility purposes if given alone
as first-line therapy

- At least 1 week since prior radiotherapy

- At least 21 days since prior and no other concurrent chemotherapy

- Prior adjuvant therapy allowed provided patient received one cytotoxic chemotherapy
regimen as treatment for metastatic disease

- Prior bevacizumab allowed

Exclusion criteria:

- Two or more cytotoxic chemotherapy regimens as treatment for metastatic disease

- Prior therapy with monoclonal antibody directed at the EGFR pathway

- Prior therapy with a vinca alkaloid in the metastatic setting

- Concurrent bevacizumab

- Other concurrent investigational agent(s)

- Concurrent colony-stimulating factors as primary prophylaxis for the prevention of
febrile neutropenia

- Concurrent CYP3A4 inhibitor(s)