Chemotherapy-Induced Cognitive Change and DNA Damage in Breast Cancer Survivors

Inclusion Criteria:

- Breast cancer survivors (Stage I-III) 2-6 years post all cancer treatments, but
currently receiving hormone therapy.

- History of treatment with chemotherapy and/or hormonal therapy, or hormone therapy
only.

- No evidence of active/recurrent disease.

- Less than 70 years old at time of recruitment.

- Post-menopausal prior to initial treatment.

- In the judgment of the consenting professional, is able to provide informed consent.

- Patient is able to understand English, through verbal and written communication.

Exclusion Criteria:

- Recurrence of breast cancer or diagnosis of another cancer except basal cell
carcinoma.

- Exposure to chemotherapy or radiation therapy for any medical condition unrelated to
breast cancer.

- Neurobehavioral risk factors including history of neurological disorder, or moderate
to severe head trauma (loss of consciousness > 60 min or evidence of structural brain
changes on imaging).

- Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease,
multiple sclerosis, etc.

- Self-reported sleep disorders that could influence cognitive functioning including
sleep apnea and chronic fatigue syndrome.

- Self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder
(untreated), bipolar disorder, schizophrenia.

- Disorder (DSM-IV), major affective disorder (untreated), bipolar disorder,
schizophrenia.

- Male.

Healthy Control

Inclusion Criteria:

- Have had no diagnosis of cancer except basal cell carcinoma.

- Less than 70 years old at time of recruitment.

- Post-menopausal.

- In the judgment of the consenting professional, is able to provide informed consent.

- Patient is able to understand English, through verbal and written communication

Healthy Control Exclusion Criteria:

- Exposure to chemotherapy or radiation therapy for any medical condition.

- Neurobehavioral risk factors including history of neurological disorder, or moderate
to severe head trauma (loss of consciousness > 60 min or evidence of structural brain
changes on imaging).

- Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease,
multiple sclerosis etc.

- Self-reported sleep disorders that could influence cognitive functioning including
sleep apnea and chronic fatigue syndrome.

- Self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder
(untreated), bipolar disorder, schizophrenia.

- Male.