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Assessment and Rehabilitation of Cognitive Impairments in Pediatric Survivors of Cancer


N/A
9 Years
16 Years
Open (Enrolling)
Both
Neoplasms

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Trial Information

Assessment and Rehabilitation of Cognitive Impairments in Pediatric Survivors of Cancer


The purpose of this study is to help determine specific cognitive-behavioral and
neurobiologic impairments associated with chemotherapy treatments in children with cancer
and to assess the efficacy of a cognitive intervention program for improving cognitive
impairments in these children.


Inclusion Criteria:



- 5 children with any type of cancer in the initial stages of chemotherapy and/or
cranial radiation.

- 10 children with any type of cancer who have completed chemotherapy and cranial
radiation.

Exclusion Criteria:

- Children with pre-cancer/pre-chemotherapy history of brain injury, neurological,
psychiatric, neurodevelopmental and/or learning disorders including attention deficit
hyperactivity disorder will be excluded.

- Participants will be excluded for MRI contraindications such as orthodontia and
biomedical implants.

- Non-English speaking participants will be excluded due to the unavailability at this
time of translated cognitive testing and MRI assessments.

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Performance on neuropsychological testing and brain activation patterns measured by functional MRI

Outcome Time Frame:

8 weeks

Safety Issue:

No

Principal Investigator

Shelli Kesler

Investigator Role:

Principal Investigator

Investigator Affiliation:

Stanford University

Authority:

United States: Institutional Review Board

Study ID:

PEDSVAR0003

NCT ID:

NCT00490334

Start Date:

August 2007

Completion Date:

August 2014

Related Keywords:

  • Neoplasms
  • Carcinomas
  • Squamous Cel
  • Adenocarcinoma
  • Acute Lymphocytic Leukemia
  • Neoplasms
  • Cognition Disorders

Name

Location
Stanford University School of Medicine Stanford, California  94305-5317