A Clinical Trial Evaluating the Efficacy and Safety of a Combination Treatment Administered Over 3 Years in Patients at Risk of Experiencing Recurrence of Colorectal Adenomas

Inclusion Criteria:

- Patients 40-75 years of age, both sexes.

- Colonoscopy including the cecum at trial entry

- The removed adenoma(s) have be to tubular, tubulovillous or villous, and fulfill one
of the three following criteria:

1. one adenoma with diameter ≥ 1 cm

2. ≥ 2 adenomas of any size

3. an adenoma of any size and familial disposition for colorectal cancer, as long
as the person is a first degree relative with a colorectal cancer patient

Exclusion Criteria:

- Familial Adenomatous Polyposis Syndrome

- Member of a family with hereditary non-polyposis colorectal cancer (HNPCC)

- Proctocolectomy (colonic and/or rectum resection permitted).

- Inflammatory bowel disease (Crohn´s disease, Ulcerative Colitis).

- Ischemic cardiovascular disease.

- Patients with known gastro-duodenal ulcer at time of inclusion.

- Cancer within the past 5 years