Familial HNSCC Syndrome and p16 Germline Mutations
N/A
18 Years
N/A
18 Years
N/A
Open (Enrolling)
Both
Head and Neck Cancer
Both
Head and Neck Cancer
Trial Information
Familial HNSCC Syndrome and p16 Germline Mutations
OBJECTIVES:
- Measure the incidence of p16^INK4a germline mutations in patients with squamous cell
carcinoma of the head and neck and a family history of cancer.
- Determine biologic activity of identified p16^INK4a germline mutations.
OUTLINE: DNA specimens are collected for genetic and mutation analysis and examined by PCR
and flow cytometry. The activity of cells with p16 mutations is determined by cell cycle
arrest functional assay.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of squamous cell carcinoma (SCC) of the head and neck
- Must have ≥ 1 first-degree relative with any of the following cancers:
- Non-small cell lung cancer
- Melanoma
- Pancreatic cancer
- SCC of the head and neck
- Lymphoma (controls)
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Incidence of INK4a-p16 germline mutations
Safety Issue:
No
Principal Investigator
Wendell G. Yarbrough, MD, FACS
Investigator Role:
Study Chair
Investigator Affiliation:
Vanderbilt-Ingram Cancer Center
Authority:
United States: Federal Government
Study ID:
CDR0000546713
NCT ID:
NCT00482872
Start Date:
March 2004
Completion Date:
Related Keywords:
- Head and Neck Cancer
- stage I squamous cell carcinoma of the hypopharynx
- stage II squamous cell carcinoma of the hypopharynx
- stage III squamous cell carcinoma of the hypopharynx
- stage IV squamous cell carcinoma of the hypopharynx
- recurrent squamous cell carcinoma of the hypopharynx
- stage I squamous cell carcinoma of the larynx
- stage II squamous cell carcinoma of the larynx
- stage III squamous cell carcinoma of the larynx
- stage IV squamous cell carcinoma of the larynx
- recurrent squamous cell carcinoma of the larynx
- stage I squamous cell carcinoma of the lip and oral cavity
- stage II squamous cell carcinoma of the lip and oral cavity
- stage III squamous cell carcinoma of the lip and oral cavity
- stage IV squamous cell carcinoma of the lip and oral cavity
- recurrent squamous cell carcinoma of the lip and oral cavity
- metastatic squamous neck cancer with occult primary squamous cell carcinoma
- recurrent metastatic squamous neck cancer with occult primary
- untreated metastatic squamous neck cancer with occult primary
- stage I squamous cell carcinoma of the nasopharynx
- stage II squamous cell carcinoma of the nasopharynx
- stage III squamous cell carcinoma of the nasopharynx
- stage IV squamous cell carcinoma of the nasopharynx
- recurrent squamous cell carcinoma of the nasopharynx
- stage I squamous cell carcinoma of the oropharynx
- stage II squamous cell carcinoma of the oropharynx
- stage III squamous cell carcinoma of the oropharynx
- stage IV squamous cell carcinoma of the oropharynx
- stage I squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage II squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage III squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage IV squamous cell carcinoma of the paranasal sinus and nasal cavity
- recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity
- salivary gland squamous cell carcinoma
- recurrent verrucous carcinoma of the larynx
- recurrent verrucous carcinoma of the oral cavity
- stage I verrucous carcinoma of the larynx
- stage I verrucous carcinoma of the oral cavity
- stage II verrucous carcinoma of the larynx
- stage II verrucous carcinoma of the oral cavity
- stage III verrucous carcinoma of the larynx
- stage III verrucous carcinoma of the oral cavity
- stage IV verrucous carcinoma of the larynx
- stage IV verrucous carcinoma of the oral cavity
- recurrent squamous cell carcinoma of the oropharynx
- Head and Neck Neoplasms
Name | Location |
|---|---|
| Vanderbilt-Ingram Cancer Center | Nashville, Tennessee 37232-6838 |
| Vanderbilt-Ingram Cancer Center - Cool Springs | Nashville, Tennessee 37064 |
| Vanderbilt-Ingram Cancer Center at Franklin | Nashville, Tennessee 37064 |
