Inclusion Criteria

Inclusion criteria:

Women who satisfy all of the following conditions are the only subjects who will be
eligible for this study:

- Normal volunteers

- Subjects with known or suspected breast disease

- Subjects must have signed an approved consent form.

- Subjects must be ≥ 18 years old.

- The protocol nurse will check with the patient that there is no h/o kidney disease

- Normal creatinine and estimated GFR* within 30 days under the following circumstances

- Had abnormal creatinine in the last 60 days

- Are over 60 years of age

- Has received chemotherapy within the past 30 days

- Has diabetes, HIV, renal disease or hx of renal cancer

- * GFR will be calculated using:
http://www.kidney.org/professionals/kdoqi/gfr_calculator.cfm

- Patients with an eGFR>90ml/min reported within 30 days, and who have not had
intervening chemotherapy or other treatment or condition that might deteriorate renal
function, may receive any gadolinium agent.

Exclusion Criteria:

- Children will be excluded from this study.

- Pregnant women and women who are breast feeding will be excluded from this study.
(The Vanderbilt University Medical Center radiology "MRI Procedure Screening Form"
will be used to identify and exclude subjects who are pregnant or breastfeeding. A
urine pregnancy test/or serum beta HCG will also be performed for each pre-menopausal
subject.)

- Subjects found to have any constitutionally present non-MR compatible ferromagnetic
materials will be excluded from this study.

- Patients who are acutely ill who are deemed by their treating physician as not
suitable candidates for this study

- Subjects for whom an MRI is technically not feasible (e.g. breast volume, obesity)