A Multicenter,Randomized,Placebo-Controlled,Double-Blind,Phase3 Trial of Single Dose Intravesical EOquin® as a Surgical Adjuvant Instilled in Early Post Operative Period in Patients Undergoing Transurethral Resection for Noninvasive Bladder Cancer

Inclusion Criteria:

(All questions must be answered YES)

- Has the patient given written informed consent?

- Is the patient at least 18 years old?

- Does the patient have transitional cell carcinoma of the bladder with clinically
apparent stage Ta, grade G1-G2?

- If the patient is a female of childbearing potential, is she using an
acceptable/effective method of contraception?

- If the patient is a female of childbearing potential, has she had a negative serum
pregnancy test within the past 14 days?

- Is the patient willing and able to abide by the protocol?

Exclusion Criteria: (All questions must be answered NO)

- Does the patient have more than 4 bladder tumors?

- Does any single bladder tumor exceed 3.5 cm in diameter?

- Does the patient have a single, primary (no previous diagnosis of TCC) bladder tumor
<0.5 cm?

- Has the patient ever received EOquin(r)?

- Does the patient have, or has the patient ever had, any bladder tumor known to be
other than stage Ta or grade G1 or G2 (low grade [WHO/ISUP classification])?

- Does the patient have, or has the patient ever had any bladder tumor with histology
other than transitional cell carcinoma?

- Does the patient have, or has the patient ever had, CIS?

- Does the patient have an active urinary tract infection?

- Does the patient have a bleeding disorder or a screening platelet count < 100 x
10^9/L?

- Does the patient have any unstable medical condition that would make it unsafe for
him/her to undergo TUR-BT under general or spinal anesthesia?

- Does the patient have a screening hemoglobin < 10 mg/dL, a screening absolute
neutrophil count < 1.5 x 10^9/L or a screening creatinine > 2 mg/dL?

- Does the patient have a known immunodeficiency disorder?

- Has the patient received any investigational treatment within the past 30 days?

- Is the patient breast feeding?

- Does the patient have a history of interstitial cystitis?

- Does the patient have a history of allergy to red color food dye?

- Has the patient had transitional cell carcinoma of the bladder within the past 4
months?