Inclusion Criteria:

- Age >=18 years

- Karnofsky Performance Status (KPS) >=70%

- Histologic evidence of multiple myeloma, measurable relapsed or relapsed/refractory
disease for which no other approved treatment is available and clinically indicated.
In addition, patients may have undergone prior bone marrow transplantation. Disease
must be assessed within 28 days prior to treatment initiation

- Adverse Events resulting from prior chemotherapy, surgery, or radiotherapy, must have
resolved to acceptable grades

- Adequate bone marrow, renal, adrenal, pancreatic and liver function

- Hemoglobin >= 8 g/dL

- Absolute neutrophil count >= 0.5 x 10^9 /L

- Platelet count >= 30 x 10^9 /L (without transfusions)

- Signed informed consent form

- Creatinine clearance >= 40 mL/min

- Must have received at least two cycles of carfilzomib (as a single agent or in
combination with other agents) and subsequently had disease progression during or
within 60 days of therapy

Exclusion Criteria:

- Administration of chemotherapy, biological, immunotherapy or investigational agent
within 14 days; 7 days for biologically targeted therapies (6 weeks for nitrosourea
and 12 weeks for BMT). Patients must be 2 weeks from radiation therapy.

- Patient's with > grade 1 proteinuria , untreated urinary tract infection,
pre-existing kidney disease in the investigator's assessment would impose a risk to
the patient

- Evidence of mucosal, internal bleeding and/or platelet refractory

- Significant cardiac disease

- Patients with a prior hypersensitivity reaction of CTCAE Grade > 3 to therapy
containing propylene glycol or ethanol.

- Pregnant or breast-feeding women

- Significant bacterial, viral or fungal infection

- Known to be HIV positive, or positive and active for Hepatitis A, B or C

- Any other medical conditions that would impose excessive risk to the patient