Phase I Trial of Systemic Administration of Edmonston Strain of Measles Virus, Genetically Engineered to Express NIS, With or Without Cyclophosphamide, in Patients With Recurrent or Refractory Multiple Myeloma
18 Years
N/A
Both
Multiple Myeloma and Plasma Cell Neoplasm
Trial Information
Phase I Trial of Systemic Administration of Edmonston Strain of Measles Virus, Genetically Engineered to Express NIS, With or Without Cyclophosphamide, in Patients With Recurrent or Refractory Multiple Myeloma
OBJECTIVES:
Primary
- Determine the safety and toxicity of Edmonston vaccine strain oncolytic measles virus
encoding thyroidal sodium iodide symporter (MV-NIS) when administered with or without
cyclophosphamide in patients with relapsed or refractory multiple myeloma.
- Determine the maximum tolerated dose of MV-NIS when administered with or without
cyclophosphamide in these patients.
Secondary
- Determine the time course of viral gene expression and viral elimination, and the
biodistribution of virally infected cells at various time points after treatment with
these regimens using iodine I 123 gamma camera imaging.
- Assess viral replication, viremia, viral shedding in urine and respiratory secretions,
and viral persistence after treatment with these regimens.
- Monitor humoral responses to MV-NIS in these patients.
- Explore the antimyeloma efficacy (i.e., clinical response rate, time to progression,
progression-free survival, duration of response) of the virus using standard myeloma
response criteria as well as immunoglobulin free light chain measurements.
OUTLINE: This is a dose-escalation study of oncolytic measles virus encoding thyroidal
sodium iodide symporter (MV-NIS). Patients are stratified according to receipt of
cyclophosphamide during study treatment (yes vs no). Patients are initially accrued to part
1. Once the maximum tolerated dose (MTD) of MV-NIS alone is determined, subsequent patients
are accrued to part 2.
- Part 1 (MV-NIS alone [closed to accrual as of 12/17/09]): Patients receive MV-NIS IV
over 30 minutes on day 1.
Cohorts of 3-6 patients receive escalating doses of MV-NIS until the MTD is determined. The
MTD is defined as the dose preceding that at which 2 of 6 patients experience dose-limiting
toxicity.
- Part 2 (MV-NIS and cyclophosphamide): Patients receive cyclophosphamide IV over 30
minutes on day -1 and MV-NIS IV over 30 minutes on day 1.
Cohorts of 3-6 patients receive escalating doses of MV-NIS* in combination with
cyclophosphamide until the MTD is determined. The MTD of MV-NIS is defined as in part 1.
NOTE: *Starting dose of MV-NIS is the MTD determined in part 1.
Blood and bone marrow samples are obtained for research studies, including flow cytometry,
at baseline and at week 6. Serial measurements of viral RNA in mononuclear cells are
conducted in samples of blood, saliva, and urine on days 3, 8, and 15 and are tested for
viral replication by quantitative reverse transcriptase-polymerase chain reaction. Measles
virus-specific immunity is evaluated at baseline and on day 42.
After the completion of study treatment, patients are followed periodically for 1 year.
PROJECTED ACCRUAL: A total of 54 patients will be accrued for this study.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of recurrent or refractory multiple myeloma
- Previously treated with ≥ 2 nonoverlapping chemotherapeutic combinations
- Thalidomide and corticosteroids are considered chemotherapy
- No known standard therapy that is definitely capable of extending life
expectancy exists
PATIENT CHARACTERISTICS:
- ECOG performance status 0-2
- Life expectancy ≥ 12 weeks
- Absolute neutrophil count ≥ 1,000/mm³
- Platelet count ≥ 100,000/mm³
- Hemoglobin ≥ 8.5 g/dL
- Bilirubin ≤ 1.5 times upper limit of normal (ULN)
- AST ≤ 2 times ULN
- Creatinine < 2 times ULN
- INR ≤ 1.4 times ULN
- Thyroid-stimulating hormone 0.3-5.0 mlU/L
- Free thyroxine 0.8-1.87 ng/dL
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception during and for 4 weeks after
completion of study treatment
- No uncontrolled infection
- No active tuberculosis
- No clinically significant cardiac condition or illness, including any of the
following:
- New York Heart Association class III-IV congestive heart failure
- Known symptomatic coronary artery disease
- Symptoms of coronary artery disease on systems review
- Cardiac arrhythmia (atrial fibrillation or supraventricular tachycardia)
- No active CNS disorder or seizure disorder
- No HIV positivity
- No allergy to iodine (not including reactions to IV contrast materials)
- No exposure to household individuals ≤ 15 months of age or to any household
individual with known immunodeficiency
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No prior allogeneic hematopoietic stem cell transplantation
- No prior exposure to heat-inactivated measles virus vaccine
- More than 3 weeks since prior and no other concurrent chemotherapy
- More than 4 weeks since prior and no other concurrent immunotherapy
- More than 4 weeks since prior biologic therapy
- No concurrent radiotherapy
- No other concurrent ancillary investigational therapy, including drugs, biologicals,
or gene therapy, for therapeutic intent or symptomatic control
- Concurrent bisphosphonates as maintenance therapy allowed
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Outcome Measure:
Toxicity
Safety Issue:
Yes
Principal Investigator
Angela Dispenzieri, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Mayo Clinic
Authority:
United States: Food and Drug Administration
Study ID:
MC038C
NCT ID:
NCT00450814
Start Date:
May 2007
Completion Date:
Related Keywords:
- Multiple Myeloma and Plasma Cell Neoplasm
- refractory multiple myeloma
- stage III multiple myeloma
- Neoplasms
- Multiple Myeloma
- Neoplasms, Plasma Cell
- Plasmacytoma
Name | Location |
|---|---|
| Mayo Clinic | Rochester, Minnesota 55905 |
