A Prospective Phase II Trial of Transperineal Ultrasound-Guided Brachytherapy for Locally Recurrent Prostate Adenocarcinoma Following External Beam Radiotherapy
OBJECTIVES:
Primary
- Determine the late treatment-related gastrointestinal (GI) and genitourinary (GU)
adverse events in patients with locally recurrent adenocarcinoma of the prostate
previously treated with external-beam radiotherapy who are currently receiving
transperineal ultrasound-guided iodine I 125 or palladium Pd 103 brachytherapy.
Secondary
- Determine the acute treatment-related GI and GU adverse events in patients treated with
this regimen.
- Determine the overall survival of patients treated with this regimen.
- Determine the disease-free survival of patients treated with this regimen.
- Determine the disease-specific survival of patients treated with this regimen.
- Determine clinical patterns of tumor recurrence (time to local tumor progression or
distant failure) in patients treated with this regimen.
- Determine the time to biochemical failure in patients treated with this regimen.
- Determine the post-brachytherapy dosimetric coverage in patients treated with this
regimen.
OUTLINE: This is a prospective, multicenter study.
Patients undergo transperineal ultrasound-guided iodine I 125 or palladium Pd 103
brachytherapy.
Patients are followed every 3 months for 1 year, every 6 months for 4 years, and then
annually thereafter.
PROJECTED ACCRUAL: A total of 96 patients will be accrued for this study.
Interventional
Primary Purpose: Treatment
Late treatment-related gastrointestinal (GI) and genitourinary (GU) adverse events
Yes
Juanita M. Crook, MD
Study Chair
British Columbia Cancer Agency
Unspecified
CDR0000533887
NCT00450411
May 2007
Name | Location |
---|---|
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia, Pennsylvania 19107 |
Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center | Milwaukee, Wisconsin 53201-2901 |
McDowell Cancer Center at Akron General Medical Center | Akron, Ohio 44307 |
Winship Cancer Institute of Emory University | Atlanta, Georgia 30322 |
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | St. Louis, Missouri 63110 |
California Cancer Center - Woodward Park Office | Fresno, California 93720 |
West Allis Memorial Hospital | West Allis, Wisconsin 53227 |
Flower Hospital Cancer Center | Sylvania, Ohio 43560 |
Arizona Oncology Services Foundation | Phoenix, Arizona 85013 |
Cancer Institute at St. John's Hospital | Springfield, Illinois 62701 |
University of Colorado Cancer Center at UC Health Sciences Center | Aurora, Colorado 80045 |
Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters | Saint Peters, Missouri 63376 |
Robinson Radiation Oncology | Ravenna, Ohio 44266 |