Molecular Epidemiology of Barrett's Esophagus
18 Years
N/A
Both
Precancerous Condition
Trial Information
Molecular Epidemiology of Barrett's Esophagus
OBJECTIVES:
- Assess the role of several genetically determined factors that, in combination with
CagA status, cigarette smoking, alcohol, and diet to varying degrees, result in an
increased risk for Barrett's esophagus.
OUTLINE: This is a controlled study.
Patients complete questionnaires about demographics, medical history, smoking and alcohol
history, current medications, frequency and chronicity of gastroesophageal reflux symptoms,
and diet history.
Blood and tissue are collected and analyzed by DNA-based assays and enzyme-linked
immunosorbent assay for CagA status and polymorphisms in detoxifying enzyme systems, other
xenobiotic metabolism pathways (e.g., CYP1A1, CYP2E1, CYP3A4, CYP3A5, NQO, NAT-2),
inflammatory gene pathways (e.g., IGF, IGFBF3), and in DNA repair genes or p53 pathways
(e.g., XRCC1, p53 gene).
PROJECTED ACCRUAL: A total of 350 patients will be accrued for this study.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Undergoing elective esophagogastroduodenoscopy for any of the following reasons:
- Surveillance of Barrett's esophagus
- Evaluation of severe or refractory gastroesophageal reflux disease or chest pain
thought to be due to reflux
- Gastrointestinal bleeding
PATIENT CHARACTERISTICS:
- Not pregnant
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Polymorphisms in detoxifying enzyme systems such as glutathione S-transferases (e.g., mu, theta, pi)
Principal Investigator
David C. Christiani, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Massachusetts General Hospital
Authority:
United States: Federal Government
Study ID:
CDR0000450146
NCT ID:
NCT00445653
Start Date:
August 2005
Completion Date:
Related Keywords:
- Precancerous Condition
- Barrett esophagus
- Barrett Esophagus
- Gastroesophageal Reflux
- Gastrointestinal Hemorrhage
- Precancerous Conditions
Name | Location |
|---|---|
| Massachusetts General Hospital Cancer Center | Boston, Massachusetts 02114 |
| Harvard School of Public Health | Boston, Massachusetts 02115 |
