Inclusion Criteria

- INCLUSION CRITERIA:

1. Patients must have histopathological confirmation of prostate cancer by the
Laboratory of Pathology of the NCI, Pathology Department of the National Naval
Medical Center or Pathology Department of Walter Reed Army Medical Center prior
to entering this study. Patients whose pathology specimens are no longer
available may be enrolled in the trial if the patient has a clinical course
consistent with prostate cancer and available documentation from an outside
pathology laboratory of the diagnosis. In cases where original tissue blocks or
archival biopsy material is available, all efforts should be made to have the
material forwarded to the research team for use in correlative studies.

2. Patients must have metastatic progressive androgen-independent prostate cancer.
There must be radiographic evidence of disease that has continued to progress
despite hormonal agents. Progression requires that a measurable lesion is
expanding, new lesions have appeared, and/or that PSA is continuing to rise on
successive measurements. Patients on flutamide must have disease progression at
least 4 weeks after withdrawal. Patients on bicalutamide or nilutamide must
have progression at least 6 weeks after withdrawal.

3. Patients must have received prior therapy with docetaxel for
androgen-independent prostate cancer. Any number of prior treatments are
acceptable.

4. Age greater than or equal to 18 years.

5. Life expectancy of greater than 3 months.

6. ECOG performance status less than or equal to 2 (Karnofsky greater than or equal
to 60%).

7. Patients must have normal organ and marrow function as defined below:

Absolute neutrophil count greater than or equal to 1,500/mcL

Platelets greater than or equal to 100,000/mcL

Hemoglobin greater than or equal to 8 g/dL

Total bilirubin within normal institutional limits (unless with clinical
Gilbert's syndrome)

AST(SGOT)/ALT(SGPT) less than or equal to 2.5 times institutional upper limit of
normal

Creatinine less than or equal to 1.5 times institutional upper normal
institutional limits

OR

Creatinine clearance greater than 40 mL/min/1.3 m(2) for patients with creatinin
levels above institutional normal as calculated by the Cockcroft Gault formula.

8. Patients must have recovered from any acute toxicity related to prior therapy,
including surgery. Toxicity should be less than or equal to grade 1 or returned
to baseline.

9. All patients who have not undergone bilateral surgical castration must continue
suppression of testosterone production by appropriate usage of GnRH agonists or
antagonists.

10. Patients must not have other invasive malignancies (within the past three years
with the exception of non-melanoma skin cancers or non-invasive bladder cancer).

11. AZD2171 has been shown to terminate fetal development in the rat, as expected
for a process dependent on VEGF signaling. Enrolled patients must agree to use
adequate contraception (hormonal or barrier method of birth control; abstinence)
prior to study entry, the duration of study participation and 3 months after the
end of the treatment.

12. Ability to understand and the willingness to sign a written informed consent
document.

13. Patients must have a blood pressure of less than 140/90 at the time of
enrollment. Details of antihypertensive treatment, if required, will be left up
to the primary care physician.

EXCLUSION CRITERIA:

1. Patients who have had chemotherapy, radiotherapy, or major surgery within 4 weeks (6
weeks for nitrosoureas or mitomycin C) prior to entering the study.

2. Patients may not be receiving any agents not approved by the FDA within the past four
weeks.

3. Patients with known brain metastases should be excluded from this clinical trial
because of their poor prognosis and because they often develop progressive neurologic
dysfunction that would confound the evaluation of neurologic and other adverse
events.

4. Mean QTc greater than 470 msec (with Bazett's correction) in screening
electrocardiogram or history of familial long QT syndrome.

5. Greater than +1 proteinuria on two consecutive dipsticks taken no less than 1 week
apart.

6. Uncontrolled intercurrent illness including, but not limited to hypertension, ongoing
or active infection, symptomatic congestive heart failure, unstable angina pectoris,
cardiac arrhythmia, or psychiatric illness/social situations that would limit
compliance with study requirements.

7. HIV-positive patients on combination antiretroviral therapy are ineligible because of
the potential for pharmacokinetic interactions with AZD2171.