Phase I Study Investigating the Safety and Feasibility of Combining Imatinib Mesylate (Gleevec) With Sorafenib in Patients With Androgen-Independent Chemotherapy-Failure Prostate Cancer.

Inclusion Criteria:

1. Patients 18 years of age or older.

2. Histologically documented diagnosis of Prostate Cancer regardless of Gleason score.

3. Androgen-Independent Prostate Cancer

4. At least one measurable site of disease

5. Patients must have failed one or more lines of systemic chemotherapy, regardless of
the chemotherapeutic agent used. There is NO limit to how many lines of chemotherapy
a patient can receive

6. Patients receiving anti-coagulation treatment with an agent such as heparin may be
allowed to participate. Patients on Warfarin are NOT allowed to participate.

7. Last chemotherapy exposure 4 weeks prior to study entry

8. Prior exposure to Sorafenib is allowed as long as last Sorafenib dose was 3 weeks or
more from study entry

9. Prior exposure to Gleevec is an EXCLUSION

10. Progression after chemotherapy can be demonstrated radiographically (as per RECIST
criteria) or biochemically with PSA being elevated more than 25% than previous value
as long as a repeat PSA confirms progression. (repeat PSA should be done within 3
weeks from the last one). Patients with bone-only disease are considered progressing
if there are two more lesions on a new bone scan.

11. Performance status 0,1, 2 (ECOG)

12. Adequate end organ function, defined as the following:

- total bilirubin < 1.5 x ULN, SGOT and SGPT < 2.5 x UNL, creatinine < 1.5 x ULN,
ANC > 1.0 x 109/L, platelets > 75 x 109/L.

13. Men of childbearing potential must agree to employ an effective barrier method of
birth control prior to the study entry, throughout the duration of the study and for
up to 3 months following discontinuation of study drug.

14. Written, voluntary informed consent.

15. Patients are allowed the following concurrent therapies:

- Intravenous bisphosphonates if administered for bone metastases

- LHRH analogues

- Narcotic-type medical interventions to control malignancy-related pain

Exclusion Criteria:

1. Patient has received any other investigational agents within 21 days of first day of
study drug dosing, unless the disease is rapidly progressing.

2. Patient is < 3 years free of another primary malignancy except: if the other primary
malignancy is not currently clinically significant nor requiring active intervention,
or if other primary malignancy is a basal or squamous cell skin cancer. Existence of
any other malignant disease is not allowed.

3. Patient with Grade III/IV cardiac problems

4. Patient has a severe and/or uncontrolled medical disease

5. Patient has a known brain metastasis.

6. Uncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic
pressure > 90 mmHg, despite optimal medical management.

7. Thrombolic or embolic events such as a cerebrovascular accident including transient
ischemic attacks within the past 6 months.

8. Pulmonary hemorrhage/bleeding event > CTCAE Grade 2 within 4 weeks of first dose of
study drug.

9. Any other hemorrhage/bleeding event > CTCAE Grade 3 within 4 weeks of first dose of
study drug.

10. Serious non-healing wound, ulcer, or bone fracture.

11. Use of St. John's Wort or rifampin (rifampicin).

12. Any condition that impairs patient's ability to swallow whole pills.

13. Patient has known chronic liver disease (i.e., chronic active hepatitis, and
cirrhosis).

14. Patient has a known diagnosis of human immunodeficiency virus (HIV) infection.

15. Patient previously received radiotherapy to ³ 25 % of the bone marrow

16. Patient had a major surgery within 2 weeks prior to study entry.

17. Patient with any significant history of non-compliance to medical regimens or with
inability to grant reliable informed consent.