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T Cell Repertoire Analysis of Immune Mediated Skin Diseases


Phase 3
18 Years
55 Years
Open (Enrolling)
Both
Psoriasis, Mycosis Fungoides

Thank you

Trial Information

T Cell Repertoire Analysis of Immune Mediated Skin Diseases


The aim of the study is to characterized the T cell repertoire of individuals with immune
mediated skin disease (e.g. psoriasis and mycosis fungoides). Peripheral blood with be
collected from volunteers with psoriasis, mycosis fungoides and age matched controls.
Fifteen tablespoons of blood will be collected prior to the initiation of treatment and
again after the patient shows a clinical response to treatment. The time between blood
draws will be no less than 3 months. There will be no more than two blood draws per
patient. Blood samples will be used to determine the patient's HLA haplotype via PCR and
DNA sequencing. After the patient's haplotype has been established the activated T cell
repertoire will be analyzed for clonal expansions. Clonal expansions in the T cell
repertoire will be determined by immunoscope analysis, which is a PCR based technique.


Inclusion Criteria:



- Have an immune mediated skin disease, such as psoriasis or mycosis fungoides

- Are not taking immunosuppressive medications, which may interfere with T cell
analysis.

Exclusion Criteria:

- are taking immunosuppressive medications, which may interfere with T cell analysis

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

Peripheral blood will be collected from adults ages 18-55. These samples will then be used for PCR analysis and T cell cloning.

Outcome Time Frame:

2 Years

Safety Issue:

No

Principal Investigator

Emanual Maverakis, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of California, Davis

Authority:

United States: Institutional Review Board

Study ID:

200513098-1

NCT ID:

NCT00368784

Start Date:

January 2007

Completion Date:

November 2011

Related Keywords:

  • Psoriasis
  • Mycosis Fungoides
  • Mycoses
  • Mycosis Fungoides
  • Psoriasis
  • Skin Diseases

Name

Location
University of California, Davis Department of Dermatology Sacramento, California  95816