Trial Information

Colorectal Cancer Screening Intervention for Family Members of Colorectal Cancer Patients

OBJECTIVES:

- Compare the impact of 3 interventions (generic educational print intervention, tailored
educational print intervention, or tailored educational print intervention plus
telephone counseling) on colorectal cancer screening behaviors and intentions among
siblings at increased familial risk for colorectal cancer.

Secondary

- Determine whether demographic factors, medical access, physician recommendation at
baseline, and proband (patient) characteristics (e.g., stage of disease) moderate the
impact of the interventions on colorectal screening.

- Evaluate whether knowledge, attitude, and physician recommendation variables mediate
the association between the interventions and colorectal screening, and determine
whether these variables are impacted by the interventions.

- Analyze the cost of each intervention.

OUTLINE: This is a randomized, controlled, cohort, multicenter study. Participants are
stratified according to study site. Participants are randomized to 1 of 3 intervention arms.

- Arm I: Participants receive generic educational print intervention approximately 1 week
after completing the baseline survey.

- Arm II: Participants receive tailored educational print intervention within 10 days
after completing the baseline survey and a tailored newsletter 1 month after completing
the baseline survey.

- Arm III: Participants receive tailored educational print intervention approximately
14-18 days after completing the baseline survey. Participants undergo a telephone
counseling session within 2 weeks after receiving the tailored print intervention and
receive a tailored newsletter 1 month after completing the baseline survey.

After study completion, participants are followed at 6 months and/or 1 year.

PROJECTED ACCRUAL: A total of 660 participants will be accrued for this study.