Menopausal Therapy in Women at Increased Risk for Breast Cancer: Does a Personalized Risk Assessment and Counseling Intervention Aid in Decision-Making?

Trial Information

Menopausal Therapy in Women at Increased Risk for Breast Cancer: Does a Personalized Risk Assessment and Counseling Intervention Aid in Decision-Making?

Women with a family history of breast cancer have several menopausal therapy options,
including tamoxifen, hormone therapy, alternative medications, or no treatment. This
complex decision should be based on each woman’s risk to develop breast cancer, menopausal
symptoms, preferences, and risks for other conditions. Current models in use for menopausal
therapy counseling do not include pedigree analysis, personalized risk assessment or genetic
testing in this process. The purpose of this multi-center study is to determine the effects
of a personalized risk assessment and genetic counseling intervention on knowledge, risk
perception, and decision-making in a group of healthy women who had a first-degree relative
with breast cancer. Intervention participants will be given a personalized risk assessment
for breast cancer, heart disease, osteoporosis, and uterine cancer based on family history
and personal health data.