Inclusion Criteria:

- Histologically confirmed intracranial glioblastoma multiforme or gliosarcoma

- Evidence of tumor progression by MRI or CT scan within the past 14 days AND on a
steroid dose that has been stable for ≥ 5 days

- Patients who underwent prior therapy that included interstitial brachytherapy or
stereotactic radiosurgery must have confirmation of true progressive disease rather
than radiation necrosis by either positron emission tomography or thallium scanning,
MR spectroscopy, or surgical documentation of disease

- Recent resection of recurrent or progressive tumor allowed

- Residual disease is not required

- Treatment for any number of prior relapses, defined as disease progression after
initial therapy (i.e., radiotherapy with or without chemotherapy if used as initial
treatment), allowed (phase I)

- No more than 3 prior therapies (initial therapy and therapy for 2 relapses) (phase
II)

- Each of the following is considered 1 relapse:

- Disease progression after initial therapy (i.e., radiotherapy with or without
chemotherapy if used as initial therapy)

- Underwent a surgical resection for relapsed disease and received no anticancer
therapy for up to 12 weeks after surgical resection AND then underwent a
subsequent surgical resection

- Received prior therapy for a low-grade glioma, followed by a surgical diagnosis
of glioblastoma

- Failed prior radiotherapy

- 15 unstained paraffin slides or 1 tissue block must be available from original
surgery, definitive surgery, or surgery closest to the initiation of this study
(phase II)

- Karnofsky performance status 60-100%

- WBC ≥ 3,000/mm^3

- Absolute neutrophil count ≥ 1,500/mm^3

- Platelet count ≥ 100,000/mm^3

- Hemoglobin ≥ 10 g/dL (transfusion allowed)

- AST/ALT ≤ 2.5 times upper limit of normal (ULN)

- Total bilirubin normal

- Creatinine < 1.5 mg/dL

- PT/INR ≤ 1.5 (INR < 3.0 for patients on anticoagulation therapy)

- INR < 1.1 times ULN (for patients on prophylactic anticoagulation therapy [low-dose
warfarin])

- Fasting cholesterol < 350 mg/dL (for patients receiving temsirolimus and sorafenib)

- Fasting triglycerides < 400 mg/dL (for patients receiving temsirolimus and sorafenib)

- Well-controlled hypertension (e.g., systolic blood pressure ≤ 140 mm Hg or diastolic
pressure ≤ 90 mm Hg) allowed

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective barrier contraception during and for at least 2
weeks (women) or 3 months (men) after completion of study treatment

- No peripheral neuropathy > grade 1 (for patients receiving sorafenib and tipifarnib)

- No evidence of bleeding diathesis or coagulopathy

- No history of any other cancer (except nonmelanoma skin cancer or carcinoma in situ
of the cervix), unless in complete remission and off all therapy for that disease for
≥ 3 years

- No significant traumatic injury within the past 21 days

- No active infection or serious medical illness that would preclude study treatment

- No condition that would impair ability to swallow pills (e.g., gastrointestinal tract
disease resulting in an inability to take oral medication or a requirement for IV
alimentation or active peptic ulcer disease)

- No HIV disease

- No allergies to imidazoles (e.g., clotrimazole, ketoconazole, miconazole or
econazole) or a history of allergic reactions attributed to any compound of similar
chemical or biological composition to tipifarnib (for patients receiving sorafenib
and tipifarnib)

- No other disease that would obscure toxicity or dangerously alter drug metabolism

- Recovered from prior therapy

- At least 7 days since prior noncytotoxic agents (e.g., interferon, tamoxifen,
thalidomide, or isotretinoin) (radiosensitizer does not count)

- At least 14 days since prior vincristine

- At least 21 days since prior procarbazine or major surgery

- At least 28 days since prior investigational agent or cytotoxic therapy

- At least 42 days since prior nitrosoureas or radiotherapy

- No prior sorafenib, AEE788, or vatalanib

- No prior surgical procedures affecting absorption

- No prior tipifarnib, lonafarnib, or other agents targeting farnesyl transferase (for
patients receiving sorafenib and tipifarnib)

- No prior temsirolimus or mTOR-targeting agent (phase II), rapamycin or everolimus, or
Akt-pathway inhibitors (for patients receiving sorafenib and temsirolimus)

- No prior erlotinib hydrochloride, AEE788, or other epidermal growth factor receptor
targeting agents (phase II) (for patients receiving sorafenib and erlotinib
hydrochloride)

- No concurrent enzyme-inducing antiepileptic drugs (e.g., carbamazepine,
oxcarbazepine, phenytoin, fosphenytoin, phenobarbital, or primidone)

- Dexamethasone allowed

- No concurrent hepatic cytochrome p450 enzyme-inducing anticonvulsants

- No other concurrent investigational agents or anticancer therapies, including
chemotherapy, radiotherapy, hormonal therapy, or immunotherapy

- No concurrent prophylactic filgrastim (G-CSF) or other hematopoietic
colony-stimulating factors

- Full-dose anticoagulants allowed provided both of the following criteria are met:

- In-range INR (between 2-3) on a stable dose of oral anticoagulant or on a stable
dose of low molecular weight heparin

- No active bleeding or pathological condition that carries a high risk of
bleeding (e.g., tumor involving major vessels or known varices)