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Effect of Esomeprazole on the Pharmacokinetics of BMS-275183 in Patients With Advanced Malignancies


Phase 1
18 Years
N/A
Not Enrolling
Both
Cancer

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Trial Information

Effect of Esomeprazole on the Pharmacokinetics of BMS-275183 in Patients With Advanced Malignancies


Inclusion Criteria:



- Advanced cancers excluding cancers within the blood

- Adequate kidney and liver function

- > = 4 weeks from last course of chemotherapy

Exclusion Criteria:

- Inability to swallow capsules

- Other active medical disorder

- Abnormal heart function or use of drugs that affect the heart

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

To assess the safety of taking Nexium in combination with oral taxane and the effect this combination has on oral taxane's exposure levels in the body.

Authority:

United States: Food and Drug Administration

Study ID:

CA165-030

NCT ID:

NCT00332748

Start Date:

December 2006

Completion Date:

Related Keywords:

  • Cancer

Name

Location
Local Institution Louisville, Kentucky  
Local Institution Las Vegas, Nevada  
Local Institution Newark, Delaware