Trial Information

Comparative Study of Gross Tumor Volume Definition With or Without PET Fusion for Patients With Non-Small Cell Lung Carcinoma

OBJECTIVES:

Primary

- Determine the impact of positron emission tomography (PET)/CT fusion scan and CT scan
alone, by comparing gross tumor volume (GTV) contours and three-dimensional conformal
radiotherapy treatment plans using 2 separate data sets (PET/CT fusion scan and CT scan
only), in patients with stage II or III non-small cell lung cancer who are planning to
undergo radiotherapy.

- Determine the impact of PET on GTV (cm^3), number of involved nodes, location of
involved nodes, and dosimetric measures of normal tissue toxicity (mean lung dose, V20,
and mean esophageal dose).

Secondary

- Determine the rate of elective nodal failures (nodal failures in regions that are not
intentionally irradiated to definitive doses [i.e., ipsilateral hilum, mediastinum, or
ipsilateral supraclavicular fossa]).

OUTLINE: This is a multicenter study. Patients are stratified according to neoadjuvant
chemotherapy (yes vs no).

Patients undergo a combined positron emission tomography (PET)/CT scan. Patients also
undergo a CT scan alone. A single three-dimensional conformal radiotherapy (3DCRT) plan is
generated from the combined PET/CT scan results. A single 3DCRT plan using the planning
target volume is derived from the CT scan only.

Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then
annually thereafter.

PROJECTED ACCRUAL: A total of 48 patients will be accrued for this study.